HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.863

Property	Details
Experiments	15388330, 21282515, 15929943
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0005911 - cell-cell junction GO:0006955 - immune response
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 533
+	Hs
		655407 P85A_HUMAN (1-724): 0: 596: 100.00		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Hs
		655419 P85A_HUMAN (1-724): 0: 596: 100.00		TENS4_HUMAN (98-512): 8.78e-21: 98.2: 14.12
+	Hs
		655524 P85A_HUMAN (1-724): 0: 596: 100.00		MYO16_HUMAN (111-438): 6.65e-11: 67.4: 12.90
+	Hs
		1192751 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Mm
		763395 FYN_MOUSE (573-724): 9.83e-33: 135: 22.50		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Mm
		763411 FYN_MOUSE (573-724): 9.83e-33: 135: 22.50		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57