HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	12074588, 35384245
Identification Methods	two hybrid, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 822
+	Hs
		655387 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		607886 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		609182 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		384316 P85A_HUMAN (1-724): 0: 596: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		507870 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		601463 P85A_HUMAN (1-724): 0: 596: 100.00		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		655220 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32
+	Hs
		655219 P85A_HUMAN (1-724): 0: 596: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		129160 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		434140 P85A_HUMAN (1-724): 0: 596: 100.00		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Mm
		643062 P85A_MOUSE (1-724): 0: 592: 95.99		RET_MOUSE (493-820): 7.8e-113: 371: 35.88
+	Hs
		655320 P85A_HUMAN (1-724): 0: 596: 100.00		ROR1_HUMAN (363-809): 2.11e-111: 364: 31.80
+	Hs
		655337 P85A_HUMAN (1-724): 0: 596: 100.00		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		435546 P85A_HUMAN (1-724): 0: 596: 100.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		411306 P85A_HUMAN (1-724): 0: 596: 100.00		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		655321 P85A_HUMAN (1-724): 0: 596: 100.00		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Mm
		546262 P85A_MOUSE (1-724): 0: 592: 95.99		INSR_MOUSE (513-809): 4.52e-68: 248: 42.72
+	Hs
		655504 P85A_HUMAN (1-724): 0: 596: 100.00		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Rn
		544879 P85A_RAT (1-724): 0: 580: 94.20		INSR_RAT (513-809): 7.79e-68: 247: 42.72
+	Hs
		655225 P85A_HUMAN (1-724): 0: 596: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07