HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22242145
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 594
+	Hs
		655224 P85A_HUMAN (1-724): 0: 596: 100.00		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Mm
		643078 P85A_MOUSE (1-724): 0: 592: 95.99		SHC1_MOUSE (3-593): 1.24e-176: 514: 47.55
+	Mm
		643064 P85A_MOUSE (1-724): 0: 592: 95.99		BTK_MOUSE (312-593): 2.55e-51: 189: 15.09
+	Hs
		522796 P85A_HUMAN (1-724): 0: 596: 100.00		SRC_HUMAN (361-594): 3.73e-49: 181: 18.18
+	Hs
		433263 P85A_HUMAN (1-724): 0: 596: 100.00		YES_HUMAN (355-594): 1.37e-48: 179: 17.31
+	Hs
		561382 P85A_HUMAN (1-724): 0: 596: 100.00		FER_HUMAN (424-594): 2.65e-47: 179: 25.43
+	Hs
		442782 P85A_HUMAN (1-724): 0: 596: 100.00		HCK_HUMAN (360-594): 1.32e-47: 176: 15.54
+	Hs
		655254 P85A_HUMAN (1-724): 0: 596: 100.00		ABL2_HUMAN (342-592): 8.81e-45: 173: 15.91
+	Hs
		412033 P85A_HUMAN (1-724): 0: 596: 100.00		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Hs
		433595 P85A_HUMAN (1-724): 0: 596: 100.00		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Mm
		643066 P85A_MOUSE (1-724): 0: 592: 95.99		FYN_MOUSE (438-585): 3.12e-44: 167: 20.76
+	Mm
		639435 P85A_MOUSE (1-724): 0: 592: 95.99		LYN_MOUSE (404-594): 4.65e-44: 166: 20.69
+	Hs
		655381 P85A_HUMAN (1-724): 0: 596: 100.00		SHB_HUMAN (363-590): 9.97e-43: 162: 22.36
+	Hs
		426946 P85A_HUMAN (1-724): 0: 596: 100.00		FES_HUMAN (431-594): 4.92e-36: 146: 22.56
+	Hs
		655306 P85A_HUMAN (1-724): 0: 596: 100.00		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Mm
		643091 P85A_MOUSE (1-724): 0: 592: 95.99		GRB2_MOUSE (445-594): 3.77e-35: 133: 22.08
+	Hs
		557615 P85A_HUMAN (1-724): 0: 596: 100.00		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56
+	Hs
		129173 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		HCK_HUMAN (360-594): 1.32e-47: 176: 15.54
+	Hs
		129164 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Hs
		129169 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69