HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: RHOV (Q96L33)
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)
Gene: RHOV

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 236
+	Hs
		655404 P85A_HUMAN (1-724): 0: 596: 100.00		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		655316 P85A_HUMAN (1-724): 0: 596: 100.00		RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44
+	Hs
		655307 P85A_HUMAN (1-724): 0: 596: 100.00		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Mm
		643072 P85A_MOUSE (1-724): 0: 592: 95.99		RAC1_MOUSE (32-217): 3.34e-76: 230: 53.23
+	Hs
		655294 P85A_HUMAN (1-724): 0: 596: 100.00		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		564419 P85A_HUMAN (1-724): 0: 596: 100.00		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		545215 P85A_HUMAN (1-724): 0: 596: 100.00		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		655297 P85A_HUMAN (1-724): 0: 596: 100.00		RHOA_HUMAN (33-215): 9.31e-73: 221: 42.62
+	Hs
		655295 P85A_HUMAN (1-724): 0: 596: 100.00		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Hs
		655467 P85A_HUMAN (1-724): 0: 596: 100.00		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Hs
		129312 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		129275 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44
+	Hs
		129270 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		129259 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		129193 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		129190 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		129262 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOA_HUMAN (33-215): 9.31e-73: 221: 42.62
+	Hs
		129260 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Hs
		129334 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Hs
		564631 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00