HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29395067, 33420362
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 669
+	Hs
		655278 P85A_HUMAN (1-724): 0: 596: 100.00		SMCA4_HUMAN (18-526): 1.58e-30: 130: 13.06
+	Hs
		655386 P85A_HUMAN (1-724): 0: 596: 100.00		ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88
+	Hs
		129221 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		MYH10_HUMAN (321-640): 8.77e-09: 61.2: 18.79
+	Hs
		64738 RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		70704 MYO9A_HUMAN (81-613): 5.01e-57: 213: 15.70		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Mm
		1195014 RHG32_MOUSE (14-612): 1.58e-61: 226: 14.33		TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67
+	Hs
		147860 RHG33_HUMAN (14-325): 1.09e-56: 211: 19.02		SMCA2_HUMAN (18-531): 1.58e-34: 143: 13.60
+	Hs
		200209 SRGP3_HUMAN (84-389): 6.03e-55: 206: 15.97		SMCA4_HUMAN (18-526): 1.58e-30: 130: 13.06
+	Hs
		1133710 RHG21_HUMAN (78-531): 1.19e-59: 221: 13.46		MYO5C_HUMAN (318-668): 7.57e-17: 87.4: 12.02
+	Hs
		1051315 RHG21_HUMAN (78-531): 1.19e-59: 221: 13.46		DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41
+	Hs
		1133693 RHG21_HUMAN (78-531): 1.19e-59: 221: 13.46		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		64716 RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		64621 RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		1133672 RHG21_HUMAN (78-531): 1.19e-59: 221: 13.46		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		70674 MYO9A_HUMAN (81-613): 5.01e-57: 213: 15.70		PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77
+	Hs
		725200 RHG24_HUMAN (94-443): 7.45e-57: 208: 16.76		MYH10_HUMAN (321-640): 8.77e-09: 61.2: 18.79
+	Hs
		1068686 RHG23_HUMAN (40-369): 2.83e-52: 198: 16.80		PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77
+	Hs
		149272 RGAP1_HUMAN (14-393): 1.43e-54: 200: 15.46		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		148770 MYO9B_HUMAN (128-294): 1.43e-45: 178: 27.98		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Dm
		113911 M9PAY7_DROME (322-428): 1.98e-13: 71.4: 27.78		MYSN_DROME (321-639): 1.56e-12: 73.5: 17.45