HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: NYAP2 (Q9P242)
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Gene: NYAP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	26496610, 21946561
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 653
+	Hs
		655524 P85A_HUMAN (1-724): 0: 596: 100.00		MYO16_HUMAN (5-618): 7.7e-76: 267: 35.57
+	Mm
		643105 P85A_MOUSE (1-724): 0: 592: 95.99		NYAP2_MOUSE (1-653): 2.62e-62: 221: 87.01
+	Mm
		643090 P85A_MOUSE (1-724): 0: 592: 95.99		MYO16_MOUSE (5-598): 1.25e-53: 201: 32.45
+	Hs
		655402 P85A_HUMAN (1-724): 0: 596: 100.00		NYAP1_HUMAN (53-581): 3.48e-24: 109: 26.17
+	Mm
		643100 P85A_MOUSE (1-724): 0: 592: 95.99		NYAP1_MOUSE (53-567): 2.79e-24: 110: 25.61
+	Hs
		979988 RGAP1_HUMAN (14-393): 1.43e-54: 200: 15.46		IF4G1_HUMAN (62-644): 6.17e-27: 119: 9.95
+	Hs
		1133704 RHG21_HUMAN (78-531): 1.19e-59: 221: 13.46		PRR36_HUMAN (4-634): 3.37e-09: 62.2: 11.06
+	Dm
		186282 O18683_DROME (319-465): 9.73e-10: 63.5: 20.95		Q8IQB8_DROME (206-563): 9.69e-25: 112: 13.64