HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16982329
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2, C1_1~SH2, SH2~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 847
+	Hs
		548645 P85A_HUMAN (1-724): 0: 596: 100.00		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		655471 P85A_HUMAN (1-724): 0: 596: 100.00		ECT2_HUMAN (101-625): 2.68e-83: 287: 18.71
+	Hs
		655405 P85A_HUMAN (1-724): 0: 596: 100.00		FGD2_HUMAN (95-577): 5.98e-82: 278: 14.23
+	Hs
		548749 RGAP1_HUMAN (14-393): 1.43e-54: 200: 15.46		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		562627 P85A_HUMAN (1-724): 0: 596: 100.00		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		580936 P85A_HUMAN (1-724): 0: 596: 100.00		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		655306 P85A_HUMAN (1-724): 0: 596: 100.00		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Mm
		643091 P85A_MOUSE (1-724): 0: 592: 95.99		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Hs
		129269 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		1133706 RHG21_HUMAN (78-531): 1.19e-59: 221: 13.46		ECT2_HUMAN (101-625): 2.68e-83: 287: 18.71
+	Hs
		1333752 RHG35_HUMAN (89-325): 8.1e-55: 206: 23.46		ECT2_HUMAN (101-625): 2.68e-83: 287: 18.71
+	Hs
		1127536 RHG22_HUMAN (106-573): 8.83e-56: 204: 14.05		FGD3_HUMAN (52-674): 2.18e-80: 275: 14.29
+	Hs
		924735 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		64654 RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		64687 RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		1049716 SRGP1_HUMAN (86-631): 1.15e-53: 202: 11.88		ARHG7_HUMAN (747-847): 4.63e-15: 81.8: 27.72
+	Hs
		1066027 RHG44_HUMAN (100-349): 1.55e-53: 200: 21.40		ARHG6_HUMAN (738-847): 4.4e-15: 81.8: 30.00
+	Hs
		200212 SRGP3_HUMAN (84-389): 6.03e-55: 206: 15.97		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		924893 RHG35_HUMAN (89-325): 8.1e-55: 206: 23.46		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		924636 RHG17_HUMAN (41-350): 6.97e-54: 201: 18.50		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39