HitPredict

Interactor 1: BRAF (P28028)
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf)
Gene: BRAF

Interactor 2: RAF1 (Q99N57)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.873

The method score is based on:

Property Details
Experiments 27034005, 18332145, 20141835, 22169110
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~C1_1, C1_1~Pkinase, C1_1~RBD, C1_1~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Pkinase, RBD~RBD
Common GO terms GO:0000165 - MAPK cascade
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
and 16 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 751
Mm

1 648
+ Hs
+ Gg
+ Hs
+ Mm
+ Hs
+ Hs
+ Xl
+ Mm
+ Hs
+ Hs
+ Dm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs

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Last updated: 15 Jul 2024