HitPredict

Interactor 1: PSB9 (P28065)
Proteasome subunit beta type-9 (EC 3.4.25.1) (Low molecular mass protein 2) (Macropain chain 7) (Multicatalytic endopeptidase complex chain 7) (Proteasome chain 7) (Proteasome subunit beta-1i) (Really interesting new gene 12 protein)
Gene: PSMB9

Interactor 2: PSME1 (Q06323)
Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha)
Gene: PSME1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	26186194, 28514442, 30833792, 33961781, 11745344
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PA28_beta~Proteasome
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 219 Hs			1 249
+	Hs
		656208 PSA5_HUMAN (5-219): 2.62e-78: 236: 17.90		PSME1_HUMAN (1-249): 1.57e-116: 335: 100.00
+	Hs
		656058 PSB8_HUMAN (8-219): 3.58e-75: 229: 30.05		PSME1_HUMAN (1-249): 1.57e-116: 335: 100.00
+	Hs
		656192 PSA5_HUMAN (5-219): 2.62e-78: 236: 17.90		PSME3_HUMAN (2-249): 4.48e-113: 326: 40.08
+	Hs
		656704 PSB5_HUMAN (2-219): 2.03e-73: 224: 27.15		PSME1_HUMAN (1-249): 1.57e-116: 335: 100.00
+	Hs
		986839 PSB7_HUMAN (10-205): 6.35e-72: 221: 27.04		PSME1_HUMAN (1-249): 1.57e-116: 335: 100.00
+	Hs
		637676 PSA2_HUMAN (6-217): 4.83e-72: 220: 14.48		PSME1_HUMAN (1-249): 1.57e-116: 335: 100.00
+	Hs
		656103 PSB9_HUMAN (1-219): 4.78e-76: 229: 100.00		PSME3_HUMAN (2-249): 4.48e-113: 326: 40.08
+	Hs
		638116 PSA4_HUMAN (5-217): 2.38e-71: 219: 15.49		PSME1_HUMAN (1-249): 1.57e-116: 335: 100.00
+	Hs
		899007 PSB7_HUMAN (10-205): 6.35e-72: 221: 27.04		PSME3_HUMAN (2-249): 4.48e-113: 326: 40.08
+	Hs
		637666 PSA2_HUMAN (6-217): 4.83e-72: 220: 14.48		PSME3_HUMAN (2-249): 4.48e-113: 326: 40.08
+	Hs
		656335 PSA5_HUMAN (5-219): 2.62e-78: 236: 17.90		PSME2_HUMAN (4-249): 8.75e-107: 310: 47.97
+	Hs
		638103 PSA4_HUMAN (5-217): 2.38e-71: 219: 15.49		PSME3_HUMAN (2-249): 4.48e-113: 326: 40.08
+	Dm
		1278635 PSA5_DROME (5-218): 1.43e-75: 229: 16.96		Q9V3P3_DROME (13-249): 2.65e-107: 311: 38.66
+	Hs
		656084 PSB8_HUMAN (8-219): 3.58e-75: 229: 30.05		PSME2_HUMAN (4-249): 8.75e-107: 310: 47.97
+	Hs
		656140 PSB9_HUMAN (1-219): 4.78e-76: 229: 100.00		PSME2_HUMAN (4-249): 8.75e-107: 310: 47.97
+	Dm
		1358994 Q9W470_DROME (14-205): 3.26e-72: 223: 27.08		Q9V3P3_DROME (13-249): 2.65e-107: 311: 38.66
+	Dm
		1178950 Q7K148_DROME (17-217): 1.23e-71: 221: 28.71		Q9V3P3_DROME (13-249): 2.65e-107: 311: 38.66
+	Hs
		1303494 PSB7_HUMAN (10-205): 6.35e-72: 221: 27.04		PSME2_HUMAN (4-249): 8.75e-107: 310: 47.97
+	Hs
		637753 PSA2_HUMAN (6-217): 4.83e-72: 220: 14.48		PSME2_HUMAN (4-249): 8.75e-107: 310: 47.97
+	Hs
		638215 PSA4_HUMAN (5-217): 2.38e-71: 219: 15.49		PSME2_HUMAN (4-249): 8.75e-107: 310: 47.97