HitPredict

Interactor 1: PSB9 (P28065)
Proteasome subunit beta type-9 (EC 3.4.25.1) (Low molecular mass protein 2) (Macropain chain 7) (Multicatalytic endopeptidase complex chain 7) (Proteasome chain 7) (Proteasome subunit beta-1i) (Really interesting new gene 12 protein)
Gene: PSMB9

Interactor 2: PSME4 (Q14997)
Proteasome activator complex subunit 4 (Proteasome activator PA200)
Gene: PSME4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BLM10_mid~Proteasome, DUF3437~Proteasome
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:1990111 - spermatoproteasome complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 219 Hs			1 1843
+	Hs
		656228 PSA5_HUMAN (5-219): 2.62e-78: 236: 17.90		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		656062 PSB8_HUMAN (8-219): 3.58e-75: 229: 30.05		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		656716 PSB5_HUMAN (2-219): 2.03e-73: 224: 27.15		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		1061392 PSB7_HUMAN (10-205): 6.35e-72: 221: 27.04		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		637689 PSA2_HUMAN (6-217): 4.83e-72: 220: 14.48		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		638132 PSA4_HUMAN (5-217): 2.38e-71: 219: 15.49		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		656600 PSB6_HUMAN (13-216): 4.09e-71: 218: 61.46		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Sc
		751170 PSB1_YEAST (13-212): 1.62e-76: 231: 45.27		BLM10_YEAST (74-831): 0: 722: 16.61
+	Sc
		675424 PSB5_YEAST (16-205): 1.55e-72: 223: 29.69		BLM10_YEAST (74-831): 0: 722: 16.61
+	Sc
		625943 PSB2_YEAST (11-219): 6.1e-72: 221: 27.27		BLM10_YEAST (74-831): 0: 722: 16.61