HitPredict

Interactor 1: PSA5 (P28066)
Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain)
Gene: PSMA5

Interactor 2: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.644

Property	Details
Experiments	25959826, 10527805
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 241 Hs			1 467
+	Hs
		637650 PSA2_HUMAN (3-241): 3.37e-89: 265: 30.96		PSN1_HUMAN (1-467): 0: 671: 100.00
+	Hs
		156254 PSA7_HUMAN (8-239): 7.45e-89: 264: 36.17		PSN1_HUMAN (1-467): 0: 671: 100.00
+	Hs
		834257 PSA6_HUMAN (4-241): 1.93e-88: 263: 25.93		PSN1_HUMAN (1-467): 0: 671: 100.00