HitPredict

Interactor 1: PSB4 (P28070)
Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)
Gene: PSMB4

Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	21145461, 9636170
Identification Methods	affinity chromatography technology, two hybrid, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 264 Hs			1 776
+	Hs
		656219 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		156283 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		637680 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		893665 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		656711 PSB5_HUMAN (11-252): 1.96e-70: 218: 21.07		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		637681 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		656220 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		156284 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		CUL3_HUMAN (9-776): 0: 748: 30.47