HitPredict

Interactor 1: PSB4 (P28070)
Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)
Gene: PSMB4

Interactor 2: PSMD6 (Q15008)
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)
Gene: PSMD6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 264 Hs			1 389
+	Hs
		656232 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		156291 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		637690 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		893673 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Dm
		1358531 PSB4_DROME (11-263): 3.53e-75: 231: 39.54		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Dm
		1278633 PSA5_DROME (26-255): 4.47e-75: 230: 14.23		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Dm
		1178948 Q7K148_DROME (50-242): 4.09e-74: 229: 25.91		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Sc
		675490 PSB7_YEAST (41-263): 9.78e-92: 273: 42.92		RPN7_YEAST (11-389): 3.41e-86: 269: 35.47
+	Hs
		893660 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		CSN1_HUMAN (12-389): 3.49e-93: 289: 20.25
+	Hs
		893638 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		CSN2_HUMAN (22-388): 5.37e-90: 280: 13.67
+	Sc
		689209 PSA5_YEAST (26-264): 8.42e-74: 227: 15.69		RPN7_YEAST (11-389): 3.41e-86: 269: 35.47
+	Hs
		121690 PSB4_HUMAN (1-264): 6.75e-82: 248: 100.00		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Hs
		121689 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Dm
		1180721 PSB4_DROME (11-263): 3.53e-75: 231: 39.54		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Hs
		121635 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Dm
		1180708 PSA5_DROME (26-255): 4.47e-75: 230: 14.23		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Dm
		1178939 Q7K148_DROME (50-242): 4.09e-74: 229: 25.91		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Hs
		121684 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Hs
		121719 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Sc
		675494 PSB7_YEAST (41-263): 9.78e-92: 273: 42.92		RPN6_YEAST (30-389): 1.53e-56: 192: 12.57