HitPredict

Interactor 1: PSB4 (P28070)
Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)
Gene: PSMB4

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 264 Hs			1 1083
+	Hs
		656235 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		637692 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		893675 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		1072708 PSB7_HUMAN (51-253): 3.22e-70: 219: 18.23		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		156366 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		HECW2_HUMAN (262-1082): 0: 591: 19.91
+	Hs
		1303488 PSB7_HUMAN (51-253): 3.22e-70: 219: 18.23		HECW2_HUMAN (262-1082): 0: 591: 19.91
+	Hs
		656449 PSB4_HUMAN (1-264): 6.75e-82: 248: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656207 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		156275 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656057 PSB8_HUMAN (14-254): 2.23e-75: 232: 23.29		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		637675 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		893654 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		983218 PSB7_HUMAN (51-253): 3.22e-70: 219: 18.23		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		656320 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		656264 PSA5_HUMAN (26-252): 6.98e-77: 234: 13.69		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		156320 PSA7_HUMAN (33-255): 6.14e-76: 232: 14.16		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		637712 PSA2_HUMAN (28-258): 1.95e-74: 228: 14.23		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		893701 PSA6_HUMAN (26-261): 3.03e-74: 228: 11.69		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Sc
		689205 PSA5_YEAST (26-264): 8.42e-74: 227: 15.69		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12
+	Hs
		1192178 PSB7_HUMAN (51-253): 3.22e-70: 219: 18.23		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60