HitPredict

Interactor 1: PSB6 (P28072)
Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y)
Gene: PSMB6

Interactor 2: PSMA8 (Q8TAA3)
Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like)
Gene: PSMA8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	17948026
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 239 Hs			1 256
+	Hs
		1250771 PSB7_HUMAN (28-229): 2.05e-84: 254: 30.69		PSMA8_HUMAN (1-238): 1.86e-105: 307: 100.00
+	Hs
		156341 PSB7_HUMAN (28-229): 2.05e-84: 254: 30.69		PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91
+	Hs
		156230 PSA5_HUMAN (3-230): 3.68e-84: 252: 18.75		PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91
+	Dm
		611640 Q7K148_DROME (31-218): 1.61e-87: 262: 30.69		PSA71_DROME (1-237): 2.13e-94: 279: 69.20
+	Dm
		47596 A0AQH0_DROME (25-237): 3.01e-87: 259: 57.28		PSA71_DROME (1-237): 2.13e-94: 279: 69.20
+	Dm
		1178944 Q7K148_DROME (31-218): 1.61e-87: 262: 30.69		PSA5_DROME (3-241): 1.12e-91: 272: 35.89
+	Dm
		611671 Q9VUJ1_DROME (37-219): 6.67e-85: 255: 28.96		PSA71_DROME (1-237): 2.13e-94: 279: 69.20
+	Sp
		675393 PSB5_SCHPO (13-218): 5.87e-87: 260: 26.54		PSA5_SCHPO (3-245): 1.32e-91: 272: 35.46
+	Dm
		47610 A0AQH0_DROME (25-237): 3.01e-87: 259: 57.28		PSA5_DROME (3-241): 1.12e-91: 272: 35.89
+	Sp
		675391 PSB5_SCHPO (13-218): 5.87e-87: 260: 26.54		PSA4_SCHPO (3-255): 8.15e-91: 270: 53.33
+	Dm
		1278650 Q9VUJ1_DROME (37-219): 6.67e-85: 255: 28.96		PSA5_DROME (3-241): 1.12e-91: 272: 35.89
+	Sp
		1013784 PSA5_SCHPO (3-230): 1.75e-85: 255: 20.75		PSA4_SCHPO (3-255): 8.15e-91: 270: 53.33
+	Hs
		656296 PSB7_HUMAN (28-229): 2.05e-84: 254: 30.69		PSA5_HUMAN (3-240): 2.51e-91: 271: 36.74
+	Hs
		893733 PSB7_HUMAN (28-229): 2.05e-84: 254: 30.69		PSA6_HUMAN (2-243): 1.76e-91: 271: 29.27
+	Hs
		637527 PSB7_HUMAN (28-229): 2.05e-84: 254: 30.69		PSA1_HUMAN (3-249): 1.17e-89: 267: 31.08
+	Hs
		638179 PSB7_HUMAN (28-229): 2.05e-84: 254: 30.69		PSA4_HUMAN (1-237): 2.99e-89: 266: 34.84
+	Dm
		771294 Q7K148_DROME (31-218): 1.61e-87: 262: 30.69		PSA2_DROME (4-222): 1.8e-47: 159: 40.27
+	Dm
		47598 A0AQH0_DROME (25-237): 3.01e-87: 259: 57.28		PSA2_DROME (4-222): 1.8e-47: 159: 40.27
+	Dm
		771324 Q9VUJ1_DROME (37-219): 6.67e-85: 255: 28.96		PSA2_DROME (4-222): 1.8e-47: 159: 40.27
+	Hs
		637732 PSB7_HUMAN (28-229): 2.05e-84: 254: 30.69		PSA2_HUMAN (1-240): 6.58e-46: 155: 39.51