HitPredict

Interactor 1: PSB5 (P28074)
Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X)
Gene: PSMB5

Interactor 2: UCHL5 (Q9Y5K5)
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)
Gene: UCHL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	32857986, 35271311, 34761751, 19615732, 18922472
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 263 Hs			1 329
+	Hs
		656348 PSA5_HUMAN (28-258): 1.29e-86: 259: 15.64		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		1303503 PSB7_HUMAN (39-251): 2.76e-83: 252: 25.82		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		637763 PSA2_HUMAN (30-259): 6.04e-80: 242: 18.64		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		638224 PSA4_HUMAN (32-255): 1.03e-79: 242: 18.22		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		656667 PSB6_HUMAN (43-245): 4.34e-77: 235: 31.37		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Sp
		1358105 PSA5_SCHPO (28-250): 3.7e-88: 263: 18.30		UBLH2_SCHPO (7-325): 1.13e-114: 335: 38.77
+	Sp
		999719 PSA3_SCHPO (32-262): 3.3e-83: 251: 17.21		UBLH2_SCHPO (7-325): 1.13e-114: 335: 38.77
+	Sp
		1000002 PSB2_SCHPO (53-248): 7.85e-79: 240: 27.04		UBLH2_SCHPO (7-325): 1.13e-114: 335: 38.77
+	Hs
		656147 PSB9_HUMAN (55-242): 2.58e-18: 82.8: 30.16		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Sp
		195134 PSB1_SCHPO (55-245): 2.94e-77: 235: 32.81		UBLH2_SCHPO (7-325): 1.13e-114: 335: 38.77
+	Sp
		675394 PSB5_SCHPO (50-257): 1.2e-74: 230: 61.06		UBLH2_SCHPO (7-325): 1.13e-114: 335: 38.77
+	Hs
		456500 PSA4_HUMAN (32-255): 1.03e-79: 242: 18.22		UCHL1_HUMAN (10-226): 1.03e-74: 231: 22.22
+	Hs
		656282 PSA5_HUMAN (28-258): 1.29e-86: 259: 15.64		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Hs
		1267103 PSB7_HUMAN (39-251): 2.76e-83: 252: 25.82		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Hs
		637724 PSA2_HUMAN (30-259): 6.04e-80: 242: 18.64		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Hs
		638171 PSA4_HUMAN (32-255): 1.03e-79: 242: 18.22		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Hs
		656631 PSB6_HUMAN (43-245): 4.34e-77: 235: 31.37		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29