HitPredict

Interactor 1: TMOD1 (P28289)
Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
Gene: TMOD1

Interactor 2: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Tropomodulin
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005884 - actin filament GO:0016020 - membrane GO:0030863 - cortical cytoskeleton
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 359 Hs			1 375
+	Hs
		1122520 TMOD3_HUMAN (1-345): 6.33e-150: 428: 62.14		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		474856 TMOD3_HUMAN (1-345): 6.33e-150: 428: 62.14		POTEI_HUMAN (1-375): 0: 731: 91.20
+	Hs
		657481 TMOD1_HUMAN (1-359): 2.27e-161: 457: 100.00		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		657479 TMOD1_HUMAN (1-359): 2.27e-161: 457: 100.00		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		892073 TMOD3_HUMAN (1-345): 6.33e-150: 428: 62.14		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		932411 TMOD3_HUMAN (1-345): 6.33e-150: 428: 62.14		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		915520 TMOD3_HUMAN (1-345): 6.33e-150: 428: 62.14		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		892077 TMOD2_HUMAN (1-345): 1.55e-144: 414: 59.25		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		930031 TMOD2_HUMAN (1-345): 1.55e-144: 414: 59.25		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		932417 TMOD2_HUMAN (1-345): 1.55e-144: 414: 59.25		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		886390 NAL12_HUMAN (185-323): 4.52e-17: 84.8: 19.86		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		932227 NLRC3_HUMAN (186-351): 8.99e-17: 84: 19.41		ACTC_HUMAN (2-375): 0: 592: 94.12