HitPredict

Interactor 1: TMOD1 (P28289)
Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
Gene: TMOD1

Interactor 2: FLII (Q13045)
Protein flightless-1 homolog
Gene: FLII

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	26186194, 28514442, 34079125, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Gelsolin~Tropomodulin
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0030239 - myofibril assembly
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 359 Hs			1 1269
+	Hs
		1023245 TMOD3_HUMAN (1-345): 6.33e-150: 428: 62.14		FLII_HUMAN (1-1269): 0: 1206: 100.00
+	Hs
		1023247 TMOD4_HUMAN (2-343): 3.86e-142: 408: 58.77		FLII_HUMAN (1-1269): 0: 1206: 100.00
+	Hs
		413834 TMOD1_HUMAN (1-359): 2.27e-161: 457: 100.00		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		414084 TMOD3_HUMAN (1-345): 6.33e-150: 428: 62.14		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		414088 TMOD2_HUMAN (1-345): 1.55e-144: 414: 59.25		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		657569 TMOD1_HUMAN (1-359): 2.27e-161: 457: 100.00		SCIN_HUMAN (906-1269): 3.84e-72: 258: 18.04
+	Hs
		1348584 TMOD3_HUMAN (1-345): 6.33e-150: 428: 62.14		SCIN_HUMAN (906-1269): 3.84e-72: 258: 18.04
+	Hs
		1349411 TMOD2_HUMAN (1-345): 1.55e-144: 414: 59.25		SCIN_HUMAN (906-1269): 3.84e-72: 258: 18.04
+	Hs
		260677 TMOD2_HUMAN (1-345): 1.55e-144: 414: 59.25		AVIL_HUMAN (906-1269): 3.8e-57: 215: 18.04
+	Hs
		313758 TMOD1_HUMAN (1-359): 2.27e-161: 457: 100.00		SVIL_HUMAN (1056-1267): 1.52e-21: 104: 17.69
+	Hs
		313893 TMOD3_HUMAN (1-345): 6.33e-150: 428: 62.14		SVIL_HUMAN (1056-1267): 1.52e-21: 104: 17.69
+	Hs
		1301451 NOD2_HUMAN (143-346): 9.86e-15: 77.4: 15.53		ERBIN_HUMAN (10-376): 1.85e-23: 110: 28.27