HitPredict

Interactor 1: ELK4 (P28324)
ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1)
Gene: ELK4

Interactor 2: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9130707
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 431 Hs			1 360
+	Hs
		647473 ELK4_HUMAN (1-431): 6.02e-55: 189: 100.00		MK03_HUMAN (4-358): 3.09e-154: 440: 85.92
+	Hs
		658856 ERF_HUMAN (4-371): 2.84e-46: 169: 23.56		MK01_HUMAN (1-360): 2.42e-158: 449: 100.00
+	Hs
		647519 ERF_HUMAN (4-371): 2.84e-46: 169: 23.56		MK03_HUMAN (4-358): 3.09e-154: 440: 85.92
+	Rn
		88640 D3ZJW0_RAT (4-371): 2.93e-46: 169: 23.56		MK03_RAT (15-357): 1.97e-152: 435: 88.63
+	Hs
		541984 ETS1_HUMAN (3-108): 2.13e-41: 154: 45.79		MK01_HUMAN (1-360): 2.42e-158: 449: 100.00
+	Mm
		785336 ELK1_MOUSE (1-430): 9.58e-39: 146: 30.72		MK01_MOUSE (10-360): 4.96e-158: 449: 99.72
+	Rn
		78170 B5DEX5_RAT (4-107): 1.26e-44: 154: 47.62		MK03_RAT (15-357): 1.97e-152: 435: 88.63
+	Hs
		584208 ELK1_HUMAN (1-430): 3.04e-36: 139: 31.17		MK01_HUMAN (1-360): 2.42e-158: 449: 100.00
+	Mm
		785338 ELK1_MOUSE (1-430): 9.58e-39: 146: 30.72		MK03_MOUSE (15-357): 1.88e-152: 435: 88.63
+	Hs
		584206 ELK1_HUMAN (1-430): 3.04e-36: 139: 31.17		MK03_HUMAN (4-358): 3.09e-154: 440: 85.92
+	Hs
		658826 ETV3_HUMAN (4-410): 2.26e-31: 127: 21.08		MK01_HUMAN (1-360): 2.42e-158: 449: 100.00
+	Hs
		542010 ETS1_HUMAN (3-108): 2.13e-41: 154: 45.79		MK07_HUMAN (11-355): 3.65e-140: 419: 49.28
+	Dm
		772960 PNT_DROME (3-92): 3.59e-35: 139: 55.56		ERKA_DROME (3-357): 2.75e-151: 432: 79.44
+	Hs
		647520 ETV1_HUMAN (3-147): 3.97e-28: 117: 38.62		MK03_HUMAN (4-358): 3.09e-154: 440: 85.92
+	Ce
		106124 G5EDL0_CAEEL (1-394): 3.56e-34: 134: 22.79		MPK1_CAEEL (12-357): 2.12e-143: 415: 79.77
+	Hs
		840374 ERF_HUMAN (4-371): 2.84e-46: 169: 23.56		MK14_HUMAN (18-356): 7.86e-112: 332: 48.97
+	Hs
		542017 ETS1_HUMAN (3-108): 2.13e-41: 154: 45.79		MK14_HUMAN (18-356): 7.86e-112: 332: 48.97
+	Hs
		840437 ETV1_HUMAN (3-147): 3.97e-28: 117: 38.62		MK14_HUMAN (18-356): 7.86e-112: 332: 48.97