HitPredict

Interactor 1: 5HT2C (P28335)
5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)
Gene: HTR2C

Interactor 2: GPC5C (Q9NQ84)
G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3)
Gene: GPRC5C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 441
+	Hs
		656980 5HT1B_HUMAN (16-387): 2.6e-70: 229: 25.20		GPC5C_HUMAN (1-441): 3.09e-146: 425: 100.00
+	Hs
		658305 5HT2C_HUMAN (1-458): 1.97e-103: 317: 100.00		GPC5B_HUMAN (1-381): 3.36e-84: 265: 39.65
+	Rn
		540670 5HT2A_RAT (9-458): 2.59e-84: 268: 50.11		GRM2_RAT (10-355): 2.07e-92: 299: 16.11
+	Hs
		657000 5HT2A_HUMAN (4-458): 5.97e-84: 267: 50.22		GRM2_HUMAN (10-355): 1.46e-90: 294: 16.11
+	Hs
		664337 AA2AR_HUMAN (55-454): 3.15e-64: 214: 19.86		GRM5_HUMAN (10-395): 3.08e-97: 318: 13.02
+	Hs
		429139 ADRB2_HUMAN (22-457): 4.42e-78: 250: 23.70		GPC5B_HUMAN (1-381): 3.36e-84: 265: 39.65
+	Hs
		537321 DRD2_HUMAN (306-385): 7.12e-15: 78.2: 47.50		GABR1_HUMAN (16-384): 4.96e-68: 235: 13.52
+	Hs
		277378 DRD2_HUMAN (306-385): 7.12e-15: 78.2: 47.50		GABR2_HUMAN (41-387): 7.87e-58: 206: 12.91