HitPredict

Interactor 1: SMCA1 (P28370)
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
Gene: SMARCA1

Interactor 2: TF7L2 (Q9NQB0)
Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
Gene: TCF7L2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	30833792
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1054 Hs			1 619
+	Hs
		658657 SMCA1_HUMAN (1-1054): 0: 1130: 100.00		SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89
+	Hs
		229467 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		229270 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		NSD2_HUMAN (251-564): 1.22e-30: 130: 13.97
+	Hs
		229376 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89
+	Mm
		1142014 SMCA5_MOUSE (73-1051): 0: 1068: 84.88		Q60I23_MOUSE (318-613): 2.23e-26: 111: 14.47
+	Hs
		229339 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Hs
		1059891 CHD4_HUMAN (29-960): 0: 789: 28.27		TF7L2_HUMAN (1-619): 4e-84: 277: 100.00
+	Hs
		727736 CHD3_HUMAN (31-954): 0: 791: 28.94		SOX5_HUMAN (3-485): 3.95e-38: 152: 12.73
+	Hs
		727814 CHD7_HUMAN (3-1046): 0: 780: 26.74		SOX5_HUMAN (3-485): 3.95e-38: 152: 12.73
+	Hs
		727856 CHD3_HUMAN (31-954): 0: 791: 28.94		SOX6_HUMAN (85-501): 1.65e-33: 138: 11.66
+	Hs
		1059807 CHD4_HUMAN (29-960): 0: 789: 28.27		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		331813 CHD4_HUMAN (29-960): 0: 789: 28.27		NSD2_HUMAN (251-564): 1.22e-30: 130: 13.97
+	Hs
		727934 CHD7_HUMAN (3-1046): 0: 780: 26.74		SOX6_HUMAN (85-501): 1.65e-33: 138: 11.66
+	Hs
		996636 CHD3_HUMAN (31-954): 0: 791: 28.94		SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89
+	Hs
		996673 CHD4_HUMAN (29-960): 0: 789: 28.27		SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89
+	Hs
		817986 CHD3_HUMAN (31-954): 0: 791: 28.94		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Hs
		818056 CHD4_HUMAN (29-960): 0: 789: 28.27		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Mm
		57186 CHD7_MOUSE (3-1046): 0: 788: 26.74		Q60I23_MOUSE (318-613): 2.23e-26: 111: 14.47
+	Mm
		1142004 CHD4_MOUSE (29-960): 0: 787: 28.27		Q60I23_MOUSE (318-613): 2.23e-26: 111: 14.47
+	Mm
		818727 CHD4_MOUSE (29-960): 0: 787: 28.27		SOX2_MOUSE (318-613): 2.17e-26: 111: 14.15