HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: DUS7 (Q16829)
Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2)
Gene: DUSP7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	28675297, 33961781, 9788880
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, phosphatase assay
Interaction Type	physical association, association, dephosphorylation reaction

Property	Details
Interacting Pfam domains	DSPc~Pkinase, Pkinase~Rhodanese
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070371 - ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 419
+	Mm
		926439 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS6_MOUSE (54-419): 2.23e-123: 364: 70.38
+	Hs
		658961 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS6_HUMAN (55-419): 1.06e-121: 360: 70.57
+	Rn
		926496 MK01_RAT (10-360): 4.96e-158: 449: 99.72		DUS6_RAT (55-419): 2.15e-121: 359: 70.03
+	Hs
		659102 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS10_HUMAN (31-402): 2.06e-113: 342: 30.13
+	Hs
		658919 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS4_HUMAN (64-417): 1.8e-104: 316: 31.76
+	Hs
		659034 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS9_HUMAN (55-413): 8.21e-103: 312: 53.58
+	Hs
		658960 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS5_HUMAN (60-419): 4.23e-101: 307: 30.21
+	Hs
		658798 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS1_HUMAN (60-387): 1.47e-98: 300: 34.65
+	Hs
		659043 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS16_HUMAN (58-414): 8.84e-95: 300: 30.25
+	Mm
		926403 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS2_MOUSE (57-386): 2.66e-98: 298: 34.23
+	Hs
		658903 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS2_HUMAN (57-386): 3.93e-98: 297: 35.14
+	Hs
		647475 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS1_HUMAN (60-387): 1.47e-98: 300: 34.65
+	Hs
		647553 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS2_HUMAN (57-386): 3.93e-98: 297: 35.14
+	Hs
		658923 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS8_HUMAN (57-399): 3.53e-88: 281: 30.61
+	Hs
		659006 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS19_HUMAN (196-383): 2.03e-59: 194: 32.98
+	Hs
		658858 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS3_HUMAN (229-393): 9.71e-57: 186: 30.64
+	Hs
		659081 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DS13B_HUMAN (247-386): 4.66e-55: 182: 31.51
+	Mm
		926438 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS3_MOUSE (229-392): 3.47e-55: 182: 31.40
+	Hs
		647521 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS3_HUMAN (229-393): 9.71e-57: 186: 30.64
+	Hs
		659008 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		STYX_HUMAN (247-382): 2.22e-17: 82.4: 34.75