HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: TP4A1 (Q93096)
Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)
Gene: PTP4A1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28675297
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DSPc~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005769 - early endosome GO:0007049 - cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 173
+	Hs
		658918 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		TP4A2_HUMAN (4-173): 2.63e-54: 171: 87.65
+	Hs
		658876 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		PTEN_HUMAN (5-164): 4.84e-45: 154: 20.46
+	Hs
		658971 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		TENS2_HUMAN (4-168): 1.8e-42: 152: 12.09
+	Hs
		253730 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		AUXI_HUMAN (9-164): 1.25e-38: 141: 14.97
+	Hs
		56510 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		PTPC1_HUMAN (10-171): 1.03e-36: 135: 20.44
+	Hs
		659034 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS9_HUMAN (18-167): 7.35e-35: 127: 18.30
+	Hs
		56508 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		PTPC1_HUMAN (10-171): 1.03e-36: 135: 20.44
+	Hs
		658962 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS7_HUMAN (2-171): 4.71e-33: 123: 17.24
+	Hs
		658961 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS6_HUMAN (2-173): 1.03e-32: 121: 16.38
+	Mm
		926439 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS6_MOUSE (2-170): 1.21e-32: 121: 16.09
+	Rn
		926496 MK01_RAT (10-360): 4.96e-158: 449: 99.72		DUS6_RAT (2-173): 1.03e-32: 121: 16.38
+	Hs
		647665 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS9_HUMAN (18-167): 7.35e-35: 127: 18.30
+	Hs
		647598 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS7_HUMAN (2-171): 4.71e-33: 123: 17.24
+	Hs
		647597 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS6_HUMAN (2-173): 1.03e-32: 121: 16.38
+	Rn
		600398 MK03_RAT (15-357): 1.97e-152: 435: 88.63		Q2YDV1_RAT (18-159): 4.9e-34: 125: 20.00
+	Sc
		691102 HOG1_YEAST (4-360): 8.23e-142: 410: 45.81		CDC14_YEAST (11-159): 3.24e-37: 135: 24.24
+	Sc
		562745 FUS3_YEAST (13-351): 4.45e-141: 405: 49.86		CDC14_YEAST (11-159): 3.24e-37: 135: 24.24
+	Hs
		864851 MK12_HUMAN (1-359): 6.4e-140: 403: 40.22		CC14A_HUMAN (14-169): 1.28e-36: 134: 24.39
+	Hs
		239316 MK12_HUMAN (1-359): 6.4e-140: 403: 40.22		CC14B_HUMAN (9-150): 2.21e-35: 130: 25.49
+	Dm
		772980 ERKA_DROME (3-357): 2.75e-151: 432: 79.44		DUSK3_DROME (8-171): 5.6e-25: 101: 19.53