Interactor 1: LAC1 (P28496)
Ceramide synthase LAC1 (Very-long-chain ceramide synthase LAC1) (EC 2.3.1.297)
Gene: LAC1

Interactor 2: LAG1 (P38703)
Ceramide synthase LAG1 (Longevity assurance factor 1) (Longevity assurance gene 1 protein) (Longevity assurance protein 1) (Very-long-chain ceramide synthase LAG1) (EC 2.3.1.297)
Gene: LAG1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 0.60 0.724

The method score is based on:

Property Details
Experiments 11283351, 16093310, 15692566, 18467557, 37968396
Identification Methods two hybrid pooling approach, ubiquitin reconstruction, affinity chromatography technology, two hybrid, protein complementation assay, anti tag coimmunoprecipitation, dihydrofolate reductase reconstruction
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0046513 - ceramide biosynthetic process
GO:0050291 - sphingosine N-acyltransferase activity
GO:0061576 - acyl-CoA ceramide synthase complex
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 418
Sc

1 411
+ Sc
+ Sp
+ Zm
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024