HitPredict

Interactor 1: LAC1 (P28496)
Ceramide synthase LAC1 (Very-long-chain ceramide synthase LAC1) (EC 2.3.1.297)
Gene: LAC1

Interactor 2: ELO3 (P40319)
Fatty acid elongase 3 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELO3) (Affecting plasma membrane ATPase activity protein 1) (Elongation of fatty acids protein 3) (Suppressor of RAD3 essential function protein 1) (Suppressor of Rvs161 and Rvs167 mutations protein 4) (Very-long-chain 3-oxoacyl-CoA synthase 3) (v-SNARE bypass mutant gene 1 protein)
Gene: ELO3

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	16093310, 37968396
Identification Methods	ubiquitin reconstruction, affinity chromatography technology, protein complementation assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 418 Sc			1 345
+	Sc
		752766 LAG1_YEAST (20-407): 1.66e-144: 419: 72.68		ELO3_YEAST (1-345): 1.63e-103: 309: 100.00
+	Hs
		1291819 CERS2_HUMAN (152-394): 5.23e-79: 250: 21.72		ELOV5_HUMAN (42-344): 2.06e-96: 289: 21.09
+	Hs
		1291817 CERS2_HUMAN (152-394): 5.23e-79: 250: 21.72		ELOV2_HUMAN (41-345): 9.97e-91: 275: 21.22
+	Hs
		1291800 CERS2_HUMAN (152-394): 5.23e-79: 250: 21.72		ELOV4_HUMAN (38-336): 1.92e-79: 246: 22.40
+	Hs
		1291795 CERS2_HUMAN (152-394): 5.23e-79: 250: 21.72		ELOV1_HUMAN (49-331): 4.29e-76: 237: 23.21
+	Hs
		50787 CERS2_HUMAN (152-394): 5.23e-79: 250: 21.72		ELOV7_HUMAN (47-327): 1.05e-70: 223: 20.89
+	Hs
		1291806 CERS2_HUMAN (152-394): 5.23e-79: 250: 21.72		ELOV6_HUMAN (67-318): 1.11e-63: 204: 26.28
+	Hs
		1291811 CERS2_HUMAN (152-394): 5.23e-79: 250: 21.72		ELOV3_HUMAN (54-319): 9.59e-61: 197: 21.03