HitPredict

Interactor 1: RXRB (P28702)
Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)
Gene: RXRB

Interactor 2: NR1H4 (Q96RI1)
Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
Gene: NR1H4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.929

The method score is based on:

Property Details
Experiments 26871637, 28514442, 32296183, 33961781, unassigned1304
Identification Methods two hybrid, affinity chromatography technology, two hybrid array, two hybrid prey pooling approach, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0004879 - nuclear receptor activity
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024