HitPredict

Interactor 1: S10A2 (P29034)
Protein S100-A2 (CAN19) (Protein S-100L) (S100 calcium-binding protein A2)
Gene: S100A2

Interactor 2: S10A3 (P33764)
Protein S100-A3 (Protein S-100E) (S100 calcium-binding protein A3)
Gene: S100A3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.794

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, mammalian protein protein interaction trap
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	S_100~S_100
Common GO terms	GO:0005509 - calcium ion binding GO:0046914 - transition metal ion binding GO:0048306 - calcium-dependent protein binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 98 Hs			1 101
+	Hs
		1135040 Q5T7Y6_HUMAN (2-91): 3.08e-40: 131: 52.22		Q5T7Y6_HUMAN (1-90): 9.99e-40: 130: 42.22
+	Mm
		421245 S10A4_MOUSE (2-97): 2.1e-39: 128: 61.46		S10A4_MOUSE (1-98): 1.44e-38: 126: 48.98
+	Hs
		642916 S10A2_HUMAN (1-98): 9.73e-40: 128: 100.00		S10A4_HUMAN (1-98): 8.11e-38: 124: 45.92
+	Hs
		615204 S10A2_HUMAN (1-98): 9.73e-40: 128: 100.00		S10A1_HUMAN (1-90): 8.76e-38: 123: 42.22
+	Mm
		421246 S10A4_MOUSE (2-97): 2.1e-39: 128: 61.46		S10A1_MOUSE (1-90): 7.35e-37: 121: 41.11
+	Hs
		638981 Q5T7Y6_HUMAN (2-91): 3.08e-40: 131: 52.22		S100P_HUMAN (3-91): 1.7e-35: 118: 33.71
+	Hs
		642915 S10A4_HUMAN (2-97): 2.05e-38: 125: 61.46		S10A4_HUMAN (1-98): 8.11e-38: 124: 45.92
+	Hs
		615203 S10A4_HUMAN (2-97): 2.05e-38: 125: 61.46		S10A1_HUMAN (1-90): 8.76e-38: 123: 42.22
+	Hs
		615200 S10A1_HUMAN (2-91): 3.92e-38: 124: 52.22		S10A1_HUMAN (1-90): 8.76e-38: 123: 42.22
+	Hs
		661198 S10A2_HUMAN (1-98): 9.73e-40: 128: 100.00		S10A2_HUMAN (1-97): 3.15e-36: 119: 43.30
+	Hs
		615206 S10A1_HUMAN (2-91): 3.92e-38: 124: 52.22		S10A3_HUMAN (1-101): 2.8e-37: 122: 100.00
+	Hs
		615201 S10A1_HUMAN (2-91): 3.92e-38: 124: 52.22		S100P_HUMAN (3-91): 1.7e-35: 118: 33.71
+	Hs
		380790 Q5T7Y6_HUMAN (2-91): 3.08e-40: 131: 52.22		S100B_HUMAN (3-91): 5.96e-32: 108: 38.20
+	Hs
		380742 S10A2_HUMAN (1-98): 9.73e-40: 128: 100.00		S100B_HUMAN (3-91): 5.96e-32: 108: 38.20
+	Hs
		380739 S10A4_HUMAN (2-97): 2.05e-38: 125: 61.46		S100B_HUMAN (3-91): 5.96e-32: 108: 38.20
+	Hs
		380736 S10A1_HUMAN (2-91): 3.92e-38: 124: 52.22		S100B_HUMAN (3-91): 5.96e-32: 108: 38.20
+	Hs
		416574 S10A4_HUMAN (2-97): 2.05e-38: 125: 61.46		S10A6_HUMAN (1-92): 5.66e-30: 103: 44.57