HitPredict

Interactor 1: ARRB1 (P29066)
Beta-arrestin-1 (Arrestin beta-1)
Gene: ARRB1

Interactor 2: GNRHR (P30969)
Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R)
Gene: GNRHR

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11278883
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 418 Rn			1 327
+	Hs
		208444 ARRB1_HUMAN (1-418): 0: 716: 99.04		OX1R_HUMAN (54-326): 1.05e-66: 217: 20.72
+	Hs
		781016 ARRB1_HUMAN (1-418): 0: 716: 99.04		OPRD_HUMAN (4-325): 2.86e-60: 198: 16.92
+	Hs
		441649 ARRB1_HUMAN (1-418): 0: 716: 99.04		ADRB1_HUMAN (14-323): 1.73e-57: 194: 15.69
+	Hs
		208441 ARRB2_HUMAN (1-406): 0: 623: 76.33		OX1R_HUMAN (54-326): 1.05e-66: 217: 20.72
+	Hs
		674004 ARRB2_HUMAN (1-406): 0: 623: 76.33		V2R_HUMAN (43-323): 3.36e-66: 214: 24.23
+	Hs
		428933 ARRB2_HUMAN (1-406): 0: 623: 76.33		ADRB2_HUMAN (13-323): 1.81e-65: 213: 16.01
+	Rn
		663954 ARRB2_RAT (1-406): 0: 615: 75.18		Q8VBU7_RAT (9-323): 4.54e-66: 215: 16.37
+	Dm
		115381 Q9V393_DROME (4-402): 0: 575: 59.86		M9PF00_DROME (1-327): 7.29e-76: 246: 27.57
+	Hs
		685822 ARRB2_HUMAN (1-406): 0: 623: 76.33		OPRD_HUMAN (4-325): 2.86e-60: 198: 16.92
+	Hs
		685813 ARRB2_HUMAN (1-406): 0: 623: 76.33		APJ_HUMAN (24-325): 2.7e-59: 196: 20.32
+	Hs
		441648 ARRB2_HUMAN (1-406): 0: 623: 76.33		ADRB1_HUMAN (14-323): 1.73e-57: 194: 15.69