HitPredict

Interactor 1: 1433Z (P29310)
14-3-3 protein zeta (14-3-3-like protein) (Protein Leonardo)
Gene: 14-3-3zeta

Interactor 2: YAP1 (Q45VV3)
Transcriptional coactivator yorkie (Protein yorkie) (Transcriptional coactivator YAP1 homolog)
Gene: yki

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.706

Property	Details
Experiments	26887950, 25320084, 24114784, 19900439, 17889654
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Dm			1 395
+	Dm
		955002 1433E_DROME (4-248): 2.88e-143: 403: 65.18		YAP1_DROME (1-395): 4.31e-94: 289: 100.00
+	Mm
		93264 1433E_MOUSE (5-246): 4.9e-144: 404: 66.80		E9PXB7_MOUSE (23-390): 8.4e-67: 228: 19.33
+	Hs
		683644 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		MAGI1_HUMAN (35-350): 6.59e-54: 194: 17.61
+	Hs
		808460 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		YAP1_HUMAN (32-343): 1.31e-53: 187: 30.03
+	Hs
		683193 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		YAP1_HUMAN (32-343): 1.31e-53: 187: 30.03
+	Rn
		910358 1433E_RAT (5-246): 4.9e-144: 404: 66.80		NEDD4_RAT (7-308): 5.28e-33: 132: 15.89
+	Mm
		808343 1433E_MOUSE (5-246): 4.9e-144: 404: 66.80		NEDD4_MOUSE (7-308): 1.2e-31: 129: 14.64
+	Hs
		909790 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		KIBRA_HUMAN (238-344): 1.5e-30: 126: 35.51
+	Hs
		683527 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		KIBRA_HUMAN (238-344): 1.5e-30: 126: 35.51
+	Hs
		909674 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		WWC2_HUMAN (233-344): 3.1e-30: 125: 30.97
+	Hs
		683439 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		WWC2_HUMAN (233-344): 3.1e-30: 125: 30.97
+	Hs
		125318 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		WWP2_HUMAN (128-393): 9.36e-19: 90.6: 11.94
+	Hs
		125169 1433T_HUMAN (4-248): 4.03e-143: 402: 77.14		WWP2_HUMAN (128-393): 9.36e-19: 90.6: 11.94
+	Hs
		808077 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		NEDD4_HUMAN (268-382): 1.51e-10: 65.1: 18.85
+	Hs
		683192 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		NEDD4_HUMAN (268-382): 1.51e-10: 65.1: 18.85
+	Hs
		910022 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		SAV1_HUMAN (106-381): 1.87e-10: 64: 14.29
+	Hs
		646713 1433T_HUMAN (4-248): 4.03e-143: 402: 77.14		NEDD4_HUMAN (268-382): 1.51e-10: 65.1: 18.85
+	Hs
		909930 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		NED4L_HUMAN (246-322): 8.24e-10: 62.8: 23.17
+	Hs
		683637 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		NED4L_HUMAN (246-322): 8.24e-10: 62.8: 23.17
+	Mm
		910302 1433E_MOUSE (5-246): 4.9e-144: 404: 66.80		NED4L_MOUSE (246-322): 8.6e-09: 59.4: 25.30