HitPredict

Interactor 1: 1433Z (P29310)
14-3-3 protein zeta (14-3-3-like protein) (Protein Leonardo)
Gene: 14-3-3zeta

Interactor 2: Q9VCC9 (Q9VCC9)
LD23779p (Tsc1)
Gene: Tsc1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	22068330, 27626673
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0035332 - positive regulation of hippo signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Dm			1 1100
+	Dm
		955019 1433E_DROME (4-248): 2.88e-143: 403: 65.18		Q9VCC9_DROME (1-1077): 0: 730: 100.00
+	Hs
		229841 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		KIF5C_HUMAN (440-949): 7.72e-40: 162: 14.31
+	Hs
		229840 1433T_HUMAN (4-248): 4.03e-143: 402: 77.14		KIF5C_HUMAN (440-949): 7.72e-40: 162: 14.31
+	Hs
		702879 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		KINH_HUMAN (471-955): 2.01e-37: 154: 13.83
+	Hs
		683163 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		KINH_HUMAN (471-955): 2.01e-37: 154: 13.83
+	Hs
		646668 1433T_HUMAN (4-248): 4.03e-143: 402: 77.14		KINH_HUMAN (471-955): 2.01e-37: 154: 13.83
+	Mm
		702835 1433E_MOUSE (5-246): 4.9e-144: 404: 66.80		KIF5A_MOUSE (485-1070): 7.54e-34: 143: 12.28
+	Hs
		909493 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		KIF5A_HUMAN (485-1070): 5.84e-32: 137: 12.42
+	Hs
		683303 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		KIF5A_HUMAN (485-1070): 5.84e-32: 137: 12.42
+	Hs
		728460 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		MYH11_HUMAN (391-1075): 1.77e-24: 113: 11.67
+	Hs
		646685 1433T_HUMAN (4-248): 4.03e-143: 402: 77.14		MYH11_HUMAN (391-1075): 1.77e-24: 113: 11.67
+	Hs
		522590 1433T_HUMAN (4-248): 4.03e-143: 402: 77.14		MYH7_HUMAN (621-1082): 7.9e-19: 95.2: 10.73
+	Hs
		725130 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		MYH10_HUMAN (612-1060): 1.09e-16: 88.1: 11.66
+	Hs
		909658 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		MRCKA_HUMAN (701-1074): 9.66e-17: 88.1: 15.91
+	Hs
		683425 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		MRCKA_HUMAN (701-1074): 9.66e-17: 88.1: 15.91
+	Hs
		909871 1433E_HUMAN (5-246): 4.9e-144: 404: 66.80		TSC1_HUMAN (788-1040): 4.34e-11: 69.4: 13.39
+	Mm
		910258 1433E_MOUSE (5-246): 4.9e-144: 404: 66.80		KINH_MOUSE (623-952): 5.99e-11: 69.1: 12.88
+	Hs
		646681 1433T_HUMAN (4-248): 4.03e-143: 402: 77.14		MYH9_HUMAN (742-1048): 2.42e-11: 70.4: 15.31
+	Hs
		683588 1433B_HUMAN (3-247): 2.05e-143: 403: 78.78		TSC1_HUMAN (788-1040): 4.34e-11: 69.4: 13.39
+	Mm
		910338 1433E_MOUSE (5-246): 4.9e-144: 404: 66.80		TSC1_MOUSE (788-1056): 2.21e-10: 67.1: 11.85