HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: LTK (P29376)
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
Gene: LTK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.715

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 864
+	Hs
		665364 EPHA2_HUMAN (1-976): 0: 1141: 100.00		ALK_HUMAN (4-851): 0: 701: 54.51
+	Hs
		600516 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA1_HUMAN (25-817): 9.44e-137: 433: 19.11
+	Hs
		601465 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR2_HUMAN (163-833): 6.48e-137: 429: 20.03
+	Hs
		609184 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR3_HUMAN (100-834): 2.96e-137: 429: 20.99
+	Hs
		435548 EPHA2_HUMAN (1-976): 0: 1141: 100.00		IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39
+	Hs
		665144 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHB2_HUMAN (391-796): 1.67e-127: 410: 26.21
+	Hs
		411310 EPHA2_HUMAN (1-976): 0: 1141: 100.00		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Hs
		665142 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA3_HUMAN (388-798): 3.64e-124: 400: 27.30
+	Hs
		665184 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA5_HUMAN (389-809): 8.73e-124: 400: 26.02
+	Hs
		665605 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EPHB2_HUMAN (391-796): 1.67e-127: 410: 26.21
+	Hs
		507871 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42
+	Hs
		665399 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EPHA3_HUMAN (388-798): 3.64e-124: 400: 27.30
+	Hs
		665353 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA6_HUMAN (388-809): 1.88e-109: 362: 24.74
+	Hs
		665141 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA2_HUMAN (446-813): 2.21e-109: 360: 30.38
+	Hs
		665244 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EPHA2_HUMAN (446-813): 2.21e-109: 360: 30.38
+	Hs
		665254 EPHA2_HUMAN (1-976): 0: 1141: 100.00		NTRK2_HUMAN (475-778): 2.43e-61: 224: 38.07
+	Hs
		384329 EPHA2_HUMAN (1-976): 0: 1141: 100.00		NTRK1_HUMAN (502-786): 7.75e-60: 220: 41.64
+	Hs
		665251 EPHA2_HUMAN (1-976): 0: 1141: 100.00		NTRK3_HUMAN (502-778): 1.77e-54: 205: 36.76
+	Hs
		665214 EPHA2_HUMAN (1-976): 0: 1141: 100.00		ROR1_HUMAN (504-778): 1.86e-53: 202: 40.00
+	Hs
		1072506 EPHA7_HUMAN (4-974): 0: 1128: 50.30		NTRK3_HUMAN (502-778): 1.77e-54: 205: 36.76