HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~fn3
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 168
+	Hs
		665360 EPHA2_HUMAN (1-976): 0: 1141: 100.00		KDIS_HUMAN (2-159): 8.8e-46: 161: 26.42
+	Hs
		872504 EPHA5_HUMAN (11-976): 0: 1127: 51.34		KDIS_HUMAN (2-159): 8.8e-46: 161: 26.42
+	Hs
		665439 EPHA3_HUMAN (24-976): 0: 1111: 51.19		KDIS_HUMAN (2-159): 8.8e-46: 161: 26.42
+	Hs
		665163 EPHA2_HUMAN (1-976): 0: 1141: 100.00		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Hs
		665164 EPHA2_HUMAN (1-976): 0: 1141: 100.00		CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22
+	Hs
		665280 EPHA2_HUMAN (1-976): 0: 1141: 100.00		MIB1_HUMAN (74-168): 4.43e-14: 70.7: 21.88
+	Hs
		665376 EPHA3_HUMAN (24-976): 0: 1111: 51.19		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Hs
		665591 EPHB2_HUMAN (28-973): 0: 1089: 48.29		ANK3_HUMAN (77-168): 3.08e-25: 103: 41.30
+	Hs
		665581 EPHB2_HUMAN (28-973): 0: 1089: 48.29		ANK2_HUMAN (77-168): 1.26e-23: 98.4: 40.22
+	Hs
		665490 EPHA8_HUMAN (28-975): 0: 1049: 46.72		ANS1B_HUMAN (59-156): 6.65e-16: 76.3: 37.00
+	Hs
		600539 EPHA1_HUMAN (17-967): 0: 959: 49.38		DAPK1_HUMAN (42-168): 1.97e-29: 114: 20.93
+	Hs
		600522 EPHA1_HUMAN (17-967): 0: 959: 49.38		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Hs
		600663 EPHA1_HUMAN (17-967): 0: 959: 49.38		TANC1_HUMAN (82-168): 2.68e-12: 65.7: 22.47
+	Hs
		674564 UFO_HUMAN (294-911): 1.98e-146: 459: 24.49		KDIS_HUMAN (2-159): 8.8e-46: 161: 26.42
+	Hs
		435574 IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00		CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22
+	Hs
		609438 FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65		FANK1_HUMAN (2-59): 6.06e-10: 58.4: 18.97
+	Hs
		434045 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		RAI14_HUMAN (1-135): 3.41e-37: 136: 21.32
+	Hs
		433730 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		ANK3_HUMAN (77-168): 3.08e-25: 103: 41.30
+	Hs
		433701 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		ANK2_HUMAN (77-168): 1.26e-23: 98.4: 40.22
+	Hs
		433991 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		TANC1_HUMAN (82-168): 2.68e-12: 65.7: 22.47