HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: EFNA3 (P52797)
Ephrin-A3 (EFL-2) (EHK1 ligand) (EHK1-L) (EPH-related receptor tyrosine kinase ligand 3) (LERK-3)
Gene: EFNA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23686814
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005005 - transmembrane-ephrin receptor activity GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0016525 - negative regulation of angiogenesis GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 238
+	Hs
		856319 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA3_HUMAN (23-238): 6.17e-100: 292: 100.00
+	Dr
		47532 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		A0A8M1Q1X6_DANRE (1-222): 1.73e-82: 247: 59.91
+	Dr
		1140992 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		Q90YC5_DANRE (26-221): 3.6e-81: 243: 65.82
+	Dr
		945416 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		EFNA5_DANRE (8-214): 1.47e-75: 230: 38.39
+	Hs
		595974 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EFNA1_HUMAN (16-204): 3.98e-76: 230: 39.47
+	Hs
		665181 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EFNA5_HUMAN (8-208): 1.93e-75: 229: 38.89
+	Dr
		945415 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		EFNA2_DANRE (7-187): 4.47e-68: 209: 45.90
+	Dr
		1140993 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		Q90Z31_DANRE (16-229): 1.08e-63: 203: 23.89
+	Hs
		856606 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA5_HUMAN (8-208): 1.93e-75: 229: 38.89
+	Hs
		856595 EPHA5_HUMAN (11-976): 0: 1127: 51.34		EFNA5_HUMAN (8-208): 1.93e-75: 229: 38.89
+	Mm
		139053 EPHA7_MOUSE (4-974): 0: 1125: 50.30		EFNA5_MOUSE (8-208): 3.05e-75: 229: 38.89
+	Dr
		251124 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		EFNB2_DANRE (16-226): 6.29e-62: 198: 20.00
+	Hs
		595985 EPHA4_HUMAN (1-976): 0: 1121: 50.25		EFNA1_HUMAN (16-204): 3.98e-76: 230: 39.47
+	Hs
		665180 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EFNA4_HUMAN (8-197): 2.58e-67: 208: 38.02
+	Mm
		856591 EPHA4_MOUSE (1-976): 0: 1126: 50.45		EFNB2_MOUSE (12-229): 9.61e-70: 218: 24.90
+	Hs
		856508 EPHA5_HUMAN (11-976): 0: 1127: 51.34		EFNB2_HUMAN (12-229): 4.24e-69: 216: 24.90
+	Hs
		856385 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA4_HUMAN (8-197): 2.58e-67: 208: 38.02
+	Hs
		957840 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNB1_HUMAN (11-236): 1.95e-61: 197: 19.84
+	Hs
		217642 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA2_HUMAN (22-179): 6.16e-58: 184: 49.40
+	Hs
		217636 EPHA4_HUMAN (1-976): 0: 1121: 50.25		EFNA2_HUMAN (22-179): 6.16e-58: 184: 49.40