HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: EFNA4 (P52798)
Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4)
Gene: EFNA4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 23686814
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005005 - transmembrane-ephrin receptor activity GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 201
+	Hs
		856385 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00
+	Hs
		665181 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EFNA5_HUMAN (1-161): 6.37e-74: 224: 43.37
+	Dr
		945415 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		EFNA2_DANRE (1-169): 3.39e-68: 208: 43.68
+	Dr
		945416 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		EFNA5_DANRE (2-161): 9.32e-68: 208: 41.21
+	Hs
		595974 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EFNA1_HUMAN (11-162): 3.84e-69: 211: 43.59
+	Mm
		856591 EPHA4_MOUSE (1-976): 0: 1126: 50.45		EFNB2_MOUSE (11-183): 3.95e-73: 226: 28.98
+	Hs
		856606 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA5_HUMAN (1-161): 6.37e-74: 224: 43.37
+	Hs
		856508 EPHA5_HUMAN (11-976): 0: 1127: 51.34		EFNB2_HUMAN (11-183): 1.14e-72: 224: 27.84
+	Hs
		856595 EPHA5_HUMAN (11-976): 0: 1127: 51.34		EFNA5_HUMAN (1-161): 6.37e-74: 224: 43.37
+	Dr
		251124 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		EFNB2_DANRE (29-183): 1.69e-60: 193: 32.05
+	Mm
		139053 EPHA7_MOUSE (4-974): 0: 1125: 50.30		EFNA5_MOUSE (1-161): 1.96e-73: 223: 43.98
+	Dr
		1140992 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		Q90YC5_DANRE (21-169): 4.71e-61: 191: 40.13
+	Dr
		1140993 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		Q90Z31_DANRE (14-168): 3.99e-59: 189: 26.42
+	Dr
		47532 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		A0A8M1Q1X6_DANRE (4-161): 2.54e-60: 189: 39.39
+	Hs
		595985 EPHA4_HUMAN (1-976): 0: 1121: 50.25		EFNA1_HUMAN (11-162): 3.84e-69: 211: 43.59
+	Hs
		665179 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EFNA3_HUMAN (21-169): 8.45e-61: 191: 42.50
+	Hs
		957840 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNB1_HUMAN (6-172): 1.5e-64: 204: 27.38
+	Hs
		856319 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA3_HUMAN (21-169): 8.45e-61: 191: 42.50
+	Hs
		217642 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA2_HUMAN (21-174): 3.64e-57: 181: 45.78
+	Hs
		217636 EPHA4_HUMAN (1-976): 0: 1121: 50.25		EFNA2_HUMAN (21-174): 3.64e-57: 181: 45.78