HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: EFNA5 (P52803)
Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)
Gene: EFNA5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	33961781, 20505120, 20228801
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, molecular sieving, light scattering, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 228
+	Hs
		856606 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00
+	Hs
		856595 EPHA5_HUMAN (11-976): 0: 1127: 51.34		EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00
+	Dr
		945416 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		EFNA5_DANRE (1-215): 2.65e-98: 287: 76.74
+	Mm
		139053 EPHA7_MOUSE (4-974): 0: 1125: 50.30		EFNA5_MOUSE (1-213): 5.92e-110: 316: 99.06
+	Dr
		945415 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		EFNA2_DANRE (4-169): 3.01e-74: 225: 59.28
+	Dr
		1140993 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		Q90Z31_DANRE (16-216): 7.03e-70: 218: 25.37
+	Hs
		665179 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EFNA3_HUMAN (25-225): 8.6e-75: 228: 38.79
+	Dr
		47532 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		A0A8M1Q1X6_DANRE (30-207): 8.5e-69: 211: 43.72
+	Hs
		595974 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EFNA1_HUMAN (14-198): 5.99e-74: 224: 43.01
+	Dr
		1140992 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		Q90YC5_DANRE (25-209): 9.45e-65: 201: 40.42
+	Hs
		856319 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA3_HUMAN (25-225): 8.6e-75: 228: 38.79
+	Hs
		957840 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNB1_HUMAN (9-207): 1.8e-73: 228: 25.74
+	Dr
		251124 Q5ZEW1_DANRE (1-976): 0: 1156: 50.66		EFNB2_DANRE (33-208): 6.45e-62: 198: 25.56
+	Hs
		665180 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EFNA4_HUMAN (4-191): 1.84e-67: 208: 40.21
+	Mm
		856591 EPHA4_MOUSE (1-976): 0: 1126: 50.45		EFNB2_MOUSE (14-216): 5.01e-71: 221: 22.01
+	Hs
		595985 EPHA4_HUMAN (1-976): 0: 1121: 50.25		EFNA1_HUMAN (14-198): 5.99e-74: 224: 43.01
+	Hs
		856508 EPHA5_HUMAN (11-976): 0: 1127: 51.34		EFNB2_HUMAN (13-216): 1.37e-69: 218: 22.44
+	Hs
		856385 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA4_HUMAN (4-191): 1.84e-67: 208: 40.21
+	Hs
		217642 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EFNA2_HUMAN (21-163): 7.5e-63: 196: 61.33
+	Hs
		217636 EPHA4_HUMAN (1-976): 0: 1121: 50.25		EFNA2_HUMAN (21-163): 7.5e-63: 196: 61.33