HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23874206
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 142
+	Hs
		665310 EPHA2_HUMAN (1-976): 0: 1141: 100.00		AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22
+	Hs
		872628 EPHA4_HUMAN (1-976): 0: 1121: 50.25		COPZ1_HUMAN (2-138): 3.65e-44: 144: 22.30
+	Hs
		665464 EPHA8_HUMAN (28-975): 0: 1049: 46.72		COPZ1_HUMAN (2-138): 3.65e-44: 144: 22.30
+	Hs
		674490 UFO_HUMAN (294-911): 1.98e-146: 459: 24.49		AP3S1_HUMAN (1-142): 5.3e-51: 162: 40.54
+	Rn
		78210 INSR_RAT (371-873): 7.71e-134: 438: 29.49		B5DFI3_RAT (1-142): 2.51e-51: 161: 44.37
+	Rn
		544829 INSR_RAT (371-873): 7.71e-134: 438: 29.49		AP1M1_RAT (2-137): 3.99e-44: 151: 14.71
+	Rn
		544815 INSR_RAT (371-873): 7.71e-134: 438: 29.49		AP2M1_RAT (1-138): 1.82e-41: 144: 15.22