HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	28205554, 31871319
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0010591 - regulation of lamellipodium assembly GO:0030335 - positive regulation of cell migration GO:0031256 - leading edge membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 191
+	Hs
		564420 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		564541 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		665332 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		665201 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		665208 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		665194 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		1072595 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		545218 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		925297 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		436169 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		665191 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		951011 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		900497 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545394 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		545285 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436317 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		436223 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		665276 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		892388 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		1072530 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82