HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	12400011, 35384245
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 217
+	Hs
		924590 EPHA7_HUMAN (4-974): 0: 1128: 50.30		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		872422 EPHA5_HUMAN (11-976): 0: 1127: 51.34		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		872630 EPHA4_HUMAN (1-976): 0: 1121: 50.25		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411611 EPHA2_HUMAN (1-976): 0: 1141: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		557643 EPHA5_HUMAN (11-976): 0: 1127: 51.34		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		789068 EPHA7_HUMAN (4-974): 0: 1128: 50.30		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Mm
		337625 EPHA4_MOUSE (1-976): 0: 1126: 50.45		ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46
+	Hs
		789049 EPHA4_HUMAN (1-976): 0: 1121: 50.25		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		337359 EPHA3_HUMAN (24-976): 0: 1111: 51.19		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		433601 EPHA2_HUMAN (1-976): 0: 1141: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		412104 EPHA5_HUMAN (11-976): 0: 1127: 51.34		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Mm
		763386 EPHA4_MOUSE (1-976): 0: 1126: 50.45		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		412105 EPHA4_HUMAN (1-976): 0: 1121: 50.25		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433772 EPHA7_HUMAN (4-974): 0: 1128: 50.30		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		433662 EPHA4_HUMAN (1-976): 0: 1121: 50.25		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522871 EPHA4_HUMAN (1-976): 0: 1121: 50.25		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		855777 EPHA4_HUMAN (1-976): 0: 1121: 50.25		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Hs
		412036 EPHA3_HUMAN (24-976): 0: 1111: 51.19		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433602 EPHA3_HUMAN (24-976): 0: 1111: 51.19		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522802 EPHA3_HUMAN (24-976): 0: 1111: 51.19		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58