HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: DSC2 (Q02487)
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
Gene: DSC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007155 - cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 901
+	Hs
		971014 EPHA7_HUMAN (4-974): 0: 1128: 50.30		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		872427 EPHA5_HUMAN (11-976): 0: 1127: 51.34		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		872632 EPHA4_HUMAN (1-976): 0: 1121: 50.25		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		521744 EPHA2_HUMAN (1-976): 0: 1141: 100.00		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		580236 EPHA7_HUMAN (4-974): 0: 1128: 50.30		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		580213 EPHA4_HUMAN (1-976): 0: 1121: 50.25		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		872601 EPHB4_HUMAN (14-970): 0: 986: 44.99		PCDG5_HUMAN (1-464): 8.24e-87: 299: 18.65
+	Hs
		872600 EPHB4_HUMAN (14-970): 0: 986: 44.99		PCDG6_HUMAN (1-464): 4.21e-86: 297: 17.92
+	Hs
		872599 EPHB4_HUMAN (14-970): 0: 986: 44.99		PCDG7_HUMAN (1-464): 5.52e-86: 296: 17.62
+	Hs
		537741 INSRR_HUMAN (287-911): 2.3e-146: 470: 27.55		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		411386 INSR_HUMAN (281-933): 1.71e-136: 445: 24.85		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		1048589 EPHA7_HUMAN (4-974): 0: 1128: 50.30		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		872440 EPHA5_HUMAN (11-976): 0: 1127: 51.34		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		872645 EPHA4_HUMAN (1-976): 0: 1121: 50.25		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		665396 EPHA3_HUMAN (24-976): 0: 1111: 51.19		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		872602 EPHB4_HUMAN (14-970): 0: 986: 44.99		PCDA8_HUMAN (358-864): 2.34e-50: 193: 13.02
+	Hs
		600717 EPHA1_HUMAN (17-967): 0: 959: 49.38		PCDA8_HUMAN (358-864): 2.34e-50: 193: 13.02
+	Hs
		872598 EPHB4_HUMAN (14-970): 0: 986: 44.99		PCDB3_HUMAN (517-878): 1.66e-23: 108: 9.66
+	Hs
		674578 UFO_HUMAN (294-911): 1.98e-146: 459: 24.49		PCDB3_HUMAN (517-878): 1.66e-23: 108: 9.66
+	Hs
		674419 UFO_HUMAN (294-911): 1.98e-146: 459: 24.49		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18