HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: SLAP1 (Q13239)
Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP)
Gene: SLA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.815

Property	Details
Experiments	7543898, 24457997
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 276
+	Hs
		433601 EPHA2_HUMAN (1-976): 0: 1141: 100.00		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		411611 EPHA2_HUMAN (1-976): 0: 1141: 100.00		LCK_HUMAN (2-276): 2.03e-90: 278: 29.83
+	Hs
		433772 EPHA7_HUMAN (4-974): 0: 1128: 50.30		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		433662 EPHA4_HUMAN (1-976): 0: 1121: 50.25		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		412104 EPHA5_HUMAN (11-976): 0: 1127: 51.34		FYN_HUMAN (8-274): 5.24e-90: 278: 29.03
+	Mm
		763386 EPHA4_MOUSE (1-976): 0: 1126: 50.45		FYN_MOUSE (8-275): 3.33e-90: 278: 28.93
+	Hs
		433602 EPHA3_HUMAN (24-976): 0: 1111: 51.19		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		412105 EPHA4_HUMAN (1-976): 0: 1121: 50.25		FYN_HUMAN (8-274): 5.24e-90: 278: 29.03
+	Hs
		522871 EPHA4_HUMAN (1-976): 0: 1121: 50.25		SRC_HUMAN (2-275): 2.76e-87: 271: 27.37
+	Hs
		412036 EPHA3_HUMAN (24-976): 0: 1111: 51.19		FYN_HUMAN (8-274): 5.24e-90: 278: 29.03
+	Mm
		337625 EPHA4_MOUSE (1-976): 0: 1126: 50.45		ABL1_MOUSE (2-275): 3.95e-79: 260: 23.40
+	Hs
		522802 EPHA3_HUMAN (24-976): 0: 1111: 51.19		SRC_HUMAN (2-275): 2.76e-87: 271: 27.37
+	Hs
		789068 EPHA7_HUMAN (4-974): 0: 1128: 50.30		ABL2_HUMAN (8-275): 6.54e-76: 252: 22.10
+	Hs
		789049 EPHA4_HUMAN (1-976): 0: 1121: 50.25		ABL2_HUMAN (8-275): 6.54e-76: 252: 22.10
+	Hs
		337359 EPHA3_HUMAN (24-976): 0: 1111: 51.19		ABL1_HUMAN (2-275): 1.88e-79: 261: 23.40
+	Mm
		403425 EPHB2_MOUSE (28-973): 0: 1089: 48.19		SRC_MOUSE (2-274): 3.56e-87: 271: 27.47
+	Hs
		337360 EPHB2_HUMAN (28-973): 0: 1089: 48.29		ABL1_HUMAN (2-275): 1.88e-79: 261: 23.40
+	Hs
		872709 EPHA4_HUMAN (1-976): 0: 1121: 50.25		SLAP2_HUMAN (12-248): 1.98e-74: 229: 40.74
+	Mm
		872619 EPHB2_MOUSE (28-973): 0: 1089: 48.19		ABL2_MOUSE (8-275): 7.66e-74: 246: 21.74
+	Mm
		975164 EPHA2_MOUSE (25-976): 0: 1094: 93.08		SLAP1_MOUSE (1-276): 4.48e-78: 239: 86.48