HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EphA2_TM~PK_Tyr_Ser-Thr, I-set~fn3, PK_Tyr_Ser-Thr~fn3, LRR_8~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0001570 - vasculogenesis GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0030425 - dendrite GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 822
+	Hs
		665251 EPHA2_HUMAN (1-976): 0: 1141: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		607887 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		1072506 EPHA7_HUMAN (4-974): 0: 1128: 50.30		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		607974 EPHA7_HUMAN (4-974): 0: 1128: 50.30		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		609184 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		384329 EPHA2_HUMAN (1-976): 0: 1141: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		507871 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		601465 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		665142 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32
+	Hs
		665399 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32
+	Hs
		665141 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		665244 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		665184 EPHA5_HUMAN (11-976): 0: 1127: 51.34		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		665214 EPHA2_HUMAN (1-976): 0: 1141: 100.00		ROR1_HUMAN (363-809): 2.11e-111: 364: 31.80
+	Hs
		665223 EPHA2_HUMAN (1-976): 0: 1141: 100.00		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		435548 EPHA2_HUMAN (1-976): 0: 1141: 100.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		411310 EPHA2_HUMAN (1-976): 0: 1141: 100.00		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		665364 EPHA2_HUMAN (1-976): 0: 1141: 100.00		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Hs
		968382 EPHA7_HUMAN (4-974): 0: 1128: 50.30		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Hs
		665146 EPHA2_HUMAN (1-976): 0: 1141: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07