HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: STYK1 (Q6J9G0)
Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
Gene: STYK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016310 - phosphorylation GO:0043235 - receptor complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 422
+	Hs
		507871 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		609184 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR3_HUMAN (10-409): 1.6e-125: 383: 27.01
+	Hs
		601465 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR2_HUMAN (29-417): 7.84e-125: 382: 23.64
+	Hs
		665142 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA3_HUMAN (2-408): 7.62e-122: 378: 20.49
+	Hs
		665141 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA2_HUMAN (46-411): 2.25e-121: 377: 21.95
+	Hs
		665184 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA5_HUMAN (2-408): 4.94e-121: 377: 20.33
+	Hs
		665144 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHB2_HUMAN (5-393): 2.02e-120: 376: 19.29
+	Hs
		665244 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA7_HUMAN (36-414): 1.44e-120: 375: 19.37
+	Hs
		665353 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA6_HUMAN (7-407): 1.54e-118: 371: 19.28
+	Hs
		665185 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73
+	Hs
		607887 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79
+	Hs
		665399 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EPHA3_HUMAN (2-408): 7.62e-122: 378: 20.49
+	Hs
		665383 EPHA5_HUMAN (11-976): 0: 1127: 51.34		EPHA3_HUMAN (2-408): 7.62e-122: 378: 20.49
+	Hs
		665605 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EPHB2_HUMAN (5-393): 2.02e-120: 376: 19.29
+	Hs
		872650 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73
+	Hs
		607974 EPHA7_HUMAN (4-974): 0: 1128: 50.30		FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79
+	Hs
		412104 EPHA5_HUMAN (11-976): 0: 1127: 51.34		FYN_HUMAN (92-390): 1.01e-109: 334: 28.33
+	Hs
		789068 EPHA7_HUMAN (4-974): 0: 1128: 50.30		ABL2_HUMAN (143-381): 3.74e-40: 155: 36.63