HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005925 - focal adhesion GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 1025
+	Hs
		665293 EPHA2_HUMAN (1-976): 0: 1141: 100.00		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		1072602 EPHA7_HUMAN (4-974): 0: 1128: 50.30		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		872491 EPHA5_HUMAN (11-976): 0: 1127: 51.34		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		665661 EPHB2_HUMAN (28-973): 0: 1089: 48.29		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		665375 EPHA3_HUMAN (24-976): 0: 1111: 51.19		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		600669 EPHA1_HUMAN (17-967): 0: 959: 49.38		TARA_HUMAN (231-985): 1.44e-51: 201: 35.57
+	Hs
		1189813 EPHA6_HUMAN (9-973): 0: 1089: 47.51		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89
+	Hs
		600673 EPHA1_HUMAN (17-967): 0: 959: 49.38		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		600712 EPHA1_HUMAN (17-967): 0: 959: 49.38		PKHA6_HUMAN (356-581): 1.69e-31: 135: 24.49
+	Hs
		255286 EPHA1_HUMAN (17-967): 0: 959: 49.38		HIP1R_HUMAN (626-929): 1.25e-09: 64.5: 19.56
+	Hs
		171334 EPHB6_HUMAN (28-962): 0: 871: 37.66		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		674557 UFO_HUMAN (294-911): 1.98e-146: 459: 24.49		SWP70_HUMAN (370-824): 7.27e-58: 212: 19.22
+	Hs
		609511 FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65		SCAPE_HUMAN (71-937): 4.97e-45: 179: 13.95
+	Hs
		435765 IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		674563 UFO_HUMAN (294-911): 1.98e-146: 459: 24.49		MYH2_HUMAN (122-873): 5.69e-17: 89: 9.31
+	Hs
		674470 UFO_HUMAN (294-911): 1.98e-146: 459: 24.49		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89
+	Hs
		433909 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		433831 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		434015 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		433620 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66