HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36963288
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~fn3
Common GO terms	GO:0005925 - focal adhesion GO:0030027 - lamellipodium GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 761
+	Hs
		665688 EPHB2_HUMAN (28-973): 0: 1089: 48.29		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		1072629 EPHA7_HUMAN (4-974): 0: 1128: 50.30		AGAP1_HUMAN (2-223): 4.13e-57: 211: 32.89
+	Hs
		91534 EPHA7_HUMAN (4-974): 0: 1128: 50.30		E7EUN2_HUMAN (2-223): 1.35e-54: 205: 32.89
+	Hs
		665591 EPHB2_HUMAN (28-973): 0: 1089: 48.29		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		665581 EPHB2_HUMAN (28-973): 0: 1089: 48.29		ANK2_HUMAN (162-494): 7.25e-30: 129: 9.52
+	Hs
		600670 EPHA1_HUMAN (17-967): 0: 959: 49.38		TNKS2_HUMAN (135-556): 6.36e-46: 179: 10.94
+	Hs
		310035 EPHA1_HUMAN (17-967): 0: 959: 49.38		TNKS1_HUMAN (60-480): 1.04e-37: 154: 12.78
+	Hs
		411283 INSR_HUMAN (281-933): 1.71e-136: 445: 24.85		POTEJ_HUMAN (47-683): 1.81e-59: 220: 12.31
+	Hs
		474791 FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65		POTEI_HUMAN (31-683): 3.04e-60: 222: 12.85
+	Hs
		411483 INSR_HUMAN (281-933): 1.71e-136: 445: 24.85		AGAP2_HUMAN (2-223): 3.67e-52: 198: 32.00
+	Mm
		546273 INSR_MOUSE (386-873): 2.57e-133: 436: 29.96		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Hs
		609490 FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65		ARAP1_HUMAN (8-205): 6.26e-49: 188: 29.35
+	Hs
		442894 HCK_HUMAN (591-880): 1.46e-65: 231: 42.12		ASAP1_HUMAN (2-606): 1.67e-61: 226: 17.06
+	Hs
		433925 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		ARAP2_HUMAN (7-223): 6.18e-51: 195: 27.15
+	Hs
		433730 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		433701 LYN_HUMAN (607-879): 2.06e-64: 228: 42.91		ANK2_HUMAN (162-494): 7.25e-30: 129: 9.52