HitPredict

Interactor 1: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Interactor 2: EFNB2 (P52799)
Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)
Gene: EFNB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	8559144, 9195962
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0007411 - axon guidance GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 983 Hs			1 333
+	Hs
		665390 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNB1_HUMAN (9-333): 2.72e-167: 471: 54.23
+	Hs
		856508 EPHA5_HUMAN (7-983): 0: 1202: 65.97		EFNB2_HUMAN (1-333): 0: 517: 100.00
+	Hs
		957840 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNB1_HUMAN (9-333): 2.72e-167: 471: 54.23
+	Dr
		251124 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNB2_DANRE (6-333): 2.04e-158: 448: 65.56
+	Dr
		1140993 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		Q90Z31_DANRE (15-333): 4.12e-140: 401: 47.88
+	Hs
		595975 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA1_HUMAN (10-204): 7.81e-74: 228: 22.50
+	Hs
		665379 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA3_HUMAN (22-239): 4.21e-69: 217: 26.52
+	Hs
		665380 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA4_HUMAN (12-198): 5.39e-58: 187: 24.34
+	Hs
		665382 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA5_HUMAN (15-204): 1.2e-55: 182: 23.15
+	Mm
		139054 Q8BRB1_MOUSE (1-983): 0: 1240: 96.44		EFNA5_MOUSE (15-204): 1.15e-55: 182: 23.65
+	Hs
		856319 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA3_HUMAN (22-239): 4.21e-69: 217: 26.52
+	Dr
		1140992 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		Q90YC5_DANRE (30-219): 8.7e-64: 203: 25.91
+	Dr
		47532 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		A0A8M1Q1X6_DANRE (12-219): 1.14e-58: 189: 23.15
+	Dr
		945415 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNA2_DANRE (28-177): 4.97e-58: 187: 27.27
+	Dr
		945416 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNA5_DANRE (14-166): 4.19e-55: 181: 26.83
+	Hs
		856385 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA4_HUMAN (12-198): 5.39e-58: 187: 24.34
+	Hs
		856595 EPHA5_HUMAN (7-983): 0: 1202: 65.97		EFNA5_HUMAN (15-204): 1.2e-55: 182: 23.15
+	Hs
		856606 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA5_HUMAN (15-204): 1.2e-55: 182: 23.15
+	Mm
		139053 EPHA7_MOUSE (6-979): 0: 1193: 61.77		EFNA5_MOUSE (15-204): 1.15e-55: 182: 23.65
+	Hs
		217642 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA2_HUMAN (23-160): 7.98e-51: 169: 27.03