HitPredict

Interactor 1: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 983 Hs			1 217
+	Hs
		872422 EPHA5_HUMAN (7-983): 0: 1202: 65.97		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924590 EPHA7_HUMAN (6-979): 0: 1198: 61.46		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		665574 EPHB2_HUMAN (29-981): 0: 1167: 55.90		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		337359 EPHA3_HUMAN (1-983): 0: 1248: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		412036 EPHA3_HUMAN (1-983): 0: 1248: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433602 EPHA3_HUMAN (1-983): 0: 1248: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522802 EPHA3_HUMAN (1-983): 0: 1248: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		557643 EPHA5_HUMAN (7-983): 0: 1202: 65.97		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		789068 EPHA7_HUMAN (6-979): 0: 1198: 61.46		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		412104 EPHA5_HUMAN (7-983): 0: 1202: 65.97		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433772 EPHA7_HUMAN (6-979): 0: 1198: 61.46		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Mm
		337625 EPHA4_MOUSE (23-983): 0: 1167: 63.36		ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46
+	Hs
		337360 EPHB2_HUMAN (29-981): 0: 1167: 55.90		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		665558 EPHB2_HUMAN (29-981): 0: 1167: 55.90		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Mm
		872619 EPHB2_MOUSE (29-981): 0: 1166: 55.90		ABL2_MOUSE (4-139): 1.55e-20: 91.3: 33.33
+	Mm
		763386 EPHA4_MOUSE (23-983): 0: 1167: 63.36		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433265 EPHB2_HUMAN (29-981): 0: 1167: 55.90		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		665608 EPHB2_HUMAN (29-981): 0: 1167: 55.90		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		522803 EPHB2_HUMAN (29-981): 0: 1167: 55.90		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		403425 EPHB2_MOUSE (29-981): 0: 1166: 55.90		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58