HitPredict

Interactor 1: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Interactor 2: EFNB1 (P98172)
Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)]
Gene: EFNB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9195962
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0007411 - axon guidance GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 983 Hs			1 346
+	Hs
		957840 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNB1_HUMAN (1-346): 0: 538: 100.00
+	Hs
		665381 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNB2_HUMAN (8-346): 1.88e-155: 441: 55.39
+	Hs
		856508 EPHA5_HUMAN (7-983): 0: 1202: 65.97		EFNB2_HUMAN (8-346): 1.88e-155: 441: 55.39
+	Dr
		251124 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNB2_DANRE (8-346): 9.92e-147: 418: 51.01
+	Dr
		1140993 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		Q90Z31_DANRE (13-346): 2.58e-138: 397: 45.53
+	Hs
		595975 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA1_HUMAN (11-175): 6.64e-66: 208: 31.40
+	Hs
		665379 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA3_HUMAN (31-220): 3.31e-63: 202: 21.57
+	Hs
		665382 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA5_HUMAN (13-199): 3.51e-60: 194: 26.63
+	Mm
		139054 Q8BRB1_MOUSE (1-983): 0: 1240: 96.44		EFNA5_MOUSE (13-199): 4.54e-60: 194: 26.13
+	Hs
		665380 EPHA3_HUMAN (1-983): 0: 1248: 100.00		EFNA4_HUMAN (13-211): 5.6e-53: 175: 23.42
+	Hs
		856319 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA3_HUMAN (31-220): 3.31e-63: 202: 21.57
+	Dr
		47532 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		A0A8M1Q1X6_DANRE (14-210): 2.08e-59: 192: 23.92
+	Hs
		856595 EPHA5_HUMAN (7-983): 0: 1202: 65.97		EFNA5_HUMAN (13-199): 3.51e-60: 194: 26.63
+	Dr
		945416 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNA5_DANRE (13-149): 3.11e-58: 189: 29.53
+	Hs
		856606 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA5_HUMAN (13-199): 3.51e-60: 194: 26.63
+	Dr
		945415 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		EFNA2_DANRE (16-189): 1.14e-57: 186: 23.89
+	Mm
		139053 EPHA7_MOUSE (6-979): 0: 1193: 61.77		EFNA5_MOUSE (13-199): 4.54e-60: 194: 26.13
+	Dr
		1140992 Q5ZEW1_DANRE (8-980): 0: 1205: 60.66		Q90YC5_DANRE (30-210): 1e-53: 177: 25.53
+	Hs
		856385 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA4_HUMAN (13-211): 5.6e-53: 175: 23.42
+	Hs
		217642 EPHA7_HUMAN (6-979): 0: 1198: 61.46		EFNA2_HUMAN (25-142): 1.12e-46: 159: 32.31