HitPredict

Interactor 1: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Interactor 2: CEA21 (Q3KPI0)
Carcinoembryonic antigen-related cell adhesion molecule 21
Gene: CEACAM21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.80	0.705

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ephrin_lbd~V-set, Ig_3~fn3, V-set~fn3
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 983 Hs			1 293
+	Hs
		872657 EPHA4_HUMAN (8-983): 0: 1164: 62.40		CEA21_HUMAN (1-293): 4.87e-75: 233: 100.00
+	Hs
		600584 EPHA1_HUMAN (7-973): 0: 949: 42.52		CEA21_HUMAN (1-293): 4.87e-75: 233: 100.00
+	Hs
		665160 EPHA2_HUMAN (27-983): 0: 1061: 50.47		VGFR3_HUMAN (38-238): 2.33e-16: 81.3: 16.75
+	Hs
		685227 EPHB4_HUMAN (17-977): 0: 1027: 47.44		CEAM8_HUMAN (5-253): 2.17e-20: 91.4: 15.56
+	Hs
		600632 EPHA1_HUMAN (7-973): 0: 949: 42.52		TITIN_HUMAN (62-258): 8.3e-09: 58.7: 13.89
+	Ce
		103939 VAB1_CAEEL (574-956): 2.3e-101: 344: 41.53		SAX3_CAEEL (145-292): 1.19e-20: 94.1: 16.25
+	Hs
		411995 FYN_HUMAN (615-879): 1.08e-64: 229: 44.20		VGFR1_HUMAN (17-239): 1.67e-12: 69.7: 14.58
+	Mm
		56907 FYN_MOUSE (615-879): 3.46e-64: 228: 43.82		PTPRF_MOUSE (25-173): 8.15e-10: 61.8: 16.78