HitPredict

Interactor 1: EPHA8 (P29322)
Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK)
Gene: EPHA8

Interactor 2: EFNA5 (P52803)
Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)
Gene: EFNA5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 33961781, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0048013 - ephrin receptor signaling pathway GO:0071372 - cellular response to follicle-stimulating hormone stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1005 Hs			1 228
+	Hs
		856595 EPHA5_HUMAN (2-1001): 0: 1242: 57.21		EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00
+	Hs
		856606 EPHA7_HUMAN (5-1005): 0: 1236: 56.16		EFNA5_HUMAN (1-213): 2.84e-110: 317: 100.00
+	Mm
		139053 EPHA7_MOUSE (5-1005): 0: 1232: 56.36		EFNA5_MOUSE (1-213): 5.92e-110: 316: 99.06
+	Dr
		945416 Q5ZEW1_DANRE (10-1005): 0: 1253: 54.79		EFNA5_DANRE (1-215): 2.65e-98: 287: 76.74
+	Dr
		945415 Q5ZEW1_DANRE (10-1005): 0: 1253: 54.79		EFNA2_DANRE (4-169): 3.01e-74: 225: 59.28
+	Dr
		1140993 Q5ZEW1_DANRE (10-1005): 0: 1253: 54.79		Q90Z31_DANRE (16-216): 7.03e-70: 218: 25.37
+	Dr
		47532 Q5ZEW1_DANRE (10-1005): 0: 1253: 54.79		A0A8M1Q1X6_DANRE (30-207): 8.5e-69: 211: 43.72
+	Hs
		856319 EPHA7_HUMAN (5-1005): 0: 1236: 56.16		EFNA3_HUMAN (25-225): 8.6e-75: 228: 38.79
+	Hs
		957840 EPHA7_HUMAN (5-1005): 0: 1236: 56.16		EFNB1_HUMAN (9-207): 1.8e-73: 228: 25.74
+	Hs
		856508 EPHA5_HUMAN (2-1001): 0: 1242: 57.21		EFNB2_HUMAN (13-216): 1.37e-69: 218: 22.44
+	Dr
		1140992 Q5ZEW1_DANRE (10-1005): 0: 1253: 54.79		Q90YC5_DANRE (25-209): 9.45e-65: 201: 40.42
+	Hs
		665458 EPHA8_HUMAN (1-1005): 0: 1245: 100.00		EFNA4_HUMAN (4-191): 1.84e-67: 208: 40.21
+	Dr
		251124 Q5ZEW1_DANRE (10-1005): 0: 1253: 54.79		EFNB2_DANRE (33-208): 6.45e-62: 198: 25.56
+	Hs
		595985 EPHA4_HUMAN (8-1005): 0: 1220: 55.92		EFNA1_HUMAN (14-198): 5.99e-74: 224: 43.01
+	Hs
		856385 EPHA7_HUMAN (5-1005): 0: 1236: 56.16		EFNA4_HUMAN (4-191): 1.84e-67: 208: 40.21
+	Mm
		856298 EPHB1_MOUSE (24-999): 0: 1222: 51.16		EFNB1_MOUSE (9-212): 8.99e-71: 221: 24.40
+	Rn
		454786 EPHB1_RAT (24-999): 0: 1221: 51.26		Q6P7B6_RAT (9-212): 1.82e-70: 220: 23.92
+	Hs
		217642 EPHA7_HUMAN (5-1005): 0: 1236: 56.16		EFNA2_HUMAN (21-163): 7.5e-63: 196: 61.33
+	Hs
		856348 EPHA4_HUMAN (8-1005): 0: 1220: 55.92		EFNA4_HUMAN (4-191): 1.84e-67: 208: 40.21
+	Hs
		217636 EPHA4_HUMAN (8-1005): 0: 1220: 55.92		EFNA2_HUMAN (21-163): 7.5e-63: 196: 61.33