HitPredict

Interactor 1: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10644995
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1055 Hs			1 304
+	Hs
		580937 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		665574 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		665608 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Hs
		665378 EPHA3_HUMAN (16-980): 0: 1152: 56.37		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		665643 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		802542 EPHB3_HUMAN (17-985): 0: 1142: 70.58		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Mm
		872621 EPHB2_MOUSE (1-985): 0: 1254: 99.49		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Mm
		1144837 Q8BRB1_MOUSE (7-980): 0: 1139: 55.22		CRK_MOUSE (1-304): 5.53e-68: 215: 99.67
+	Hs
		802810 EPHA4_HUMAN (6-982): 0: 1152: 58.33		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		872610 EPHB1_HUMAN (20-985): 0: 1211: 73.60		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		557644 EPHB1_HUMAN (20-985): 0: 1211: 73.60		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		855777 EPHA4_HUMAN (6-982): 0: 1152: 58.33		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		580965 EPHA4_HUMAN (6-982): 0: 1152: 58.33		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		562635 EPHA4_HUMAN (6-982): 0: 1152: 58.33		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		924590 EPHA7_HUMAN (6-982): 0: 1154: 57.46		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		665389 EPHA3_HUMAN (16-980): 0: 1152: 56.37		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		872630 EPHA4_HUMAN (6-982): 0: 1152: 58.33		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		872422 EPHA5_HUMAN (6-984): 0: 1148: 56.69		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		209018 EPHA4_HUMAN (6-982): 0: 1152: 58.33		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557643 EPHA5_HUMAN (6-984): 0: 1148: 56.69		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00